CAJ | 학술논문

目的：探讨大黄、思密达与硫酸镁、漂白土在治疗急性有机磷农药中毒的疗效。方法将76例口服有机磷中毒的重度患者随机均分2组。两组均给予彻底洗胃、适量应用长托宁及阿托品解毒，氯磷定复能剂等综合常规治疗。A组（治疗组）应用大黄导泻、思密达吸附；B组（对照组）应用硫酸镁导泻、漂白土吸附。观察首次排便时间，胃肠功能不全发生率及严重程度评分；观察胃肠功能恢复时间、阿托品化时间、意识恢复时间、胆碱酯酶活力恢复50%以上时间、阿托品和长托宁用量、药物耐受、中毒反跳、中间综合征、迟发性神经病、住院时间和死亡情况。结果治疗组各指标均优于对照组，均差异有统计学意义（均P<0.01或P<0.05）。结论思密达、大黄是目前彻底清除AOPP患者胃肠道残留毒物较好的导泻、吸附联合用药，减少了药物用量和并发症、缩短了住院时间。
목적：탐토대황、사밀체여류산미、표백토재치료급성유궤린농약중독적료효。방법장76례구복유궤린중독적중도환자수궤균분2조。량조균급여철저세위、괄량응용장탁저급아탁품해독，록린정복능제등종합상규치료。A조（치료조）응용대황도사、사밀체흡부；B조（대조조）응용류산미도사、표백토흡부。관찰수차배편시간，위장공능불전발생솔급엄중정도평분；관찰위장공능회복시간、아탁품화시간、의식회복시간、담감지매활력회복50%이상시간、아탁품화장탁저용량、약물내수、중독반도、중간종합정、지발성신경병、주원시간화사망정황。결과치료조각지표균우우대조조，균차이유통계학의의（균P<0.01혹P<0.05）。결론사밀체、대황시목전철저청제AOPP환자위장도잔류독물교호적도사、흡부연합용약，감소료약물용량화병발증、축단료주원시간。
Objective investigate the effects of Chinese rhubarb combined with Smecta in treatment of organopjophorus pesticide poisoning. Methods Seventy-six patients with organophosphorus pesticide poisoning underwent conventional treatment including thorough gastric lavage, muscular injection of penehyckiine hydrochloride, intravenous injection of atropine through micropumping, and intravenous drip of pyraloxime methylchloride. The patients were randomly divided into 2 equal groups: Group A underdoing catharsis with 200 ml of Chinese Rhubarb powder and then suspension of Smecta through gastric tube 2h later as a cycle per 4 hours for 48 hours, and Group B undergoing irrigation of magnesium sulphate solution and suspension of Fuller's earth per 4 hours as a cycle for 48 hours. The effects were observed. Results The first defecation yime, recovery time of gastrointestinal tract, time of atropinization time, consciousness recovery time, recovery time of cholinesterase activity, and length of hospial stay of Group A were all significantly shorter than those of Group B (all P <0.05); and the dosages of atropine and penehyckiine hydrochloride of Group A were both significantly lower than those of Group B (both P<0.01). The rates of drug tolerance, intermediate syndrome, poisoning rebound, and delayed neuropathy were all significantly lower than those of Group B (all P <0.05, P <0.01). Conclusion Chinese rhubarb combined with Smecta help cure organophosphorus pesticide poisoning.