CAJ | 학술논문

近年来研究证明,脂肪组织和外周血中的microRNA参与了脂肪细胞分化、胰岛素抵抗、脂肪代谢等与肥胖发生密切相关的进程.MicroRNA影响肥胖的分子学机制逐步被发现,如通过增强或抑制相关基因表达从而调控与脂肪细胞增殖、分化相关的转录因子及信号分子等.对机制的研究,为今后肥胖及肥胖相关代谢性疾病的预警及治疗提供了新的手段.
근년래연구증명,지방조직화외주혈중적microRNA삼여료지방세포분화、이도소저항、지방대사등여비반발생밀절상관적진정.MicroRNA영향비반적분자학궤제축보피발현,여통과증강혹억제상관기인표체종이조공여지방세포증식、분화상관적전록인자급신호분자등.대궤제적연구,위금후비반급비반상관대사성질병적예경급치료제공료신적수단.
Recent researches have proved that microRNA in adipose tissue and peripheral blood participates in the progress of adipocyte differentiation,insulin resistance,lipid metabolism and so on,which are closely associated with obesity.The molecular mechanisms of micmRNA on obesity have been discovered step by step.For example,transcription factors and signaling molecules related to the multiplication and differentiation of adipocytes are regulated and controlled by enhancing or restraining of relevant gene expression.The investigation of the mechanisms provides a new approach for precaution and treatment of obesity and obesity-related metabolic diseases.