中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
Chinese Journal of Epidemiology
2015年
9期
1005-1009
,共5页
再生障碍性贫血%有机磷农药%病例对照研究%Meta分析
再生障礙性貧血%有機燐農藥%病例對照研究%Meta分析
재생장애성빈혈%유궤린농약%병례대조연구%Meta분석
Aplastic anemia%Organophosphorus pesticides%Case-control study%Meta-analysis
目的 评价有机磷农药与再生障碍性贫血发病的关系,为一级预防提供科学依据.方法 检索1990年1月至2014年8月公开发表在中国生物医学文献数据库(CBM)、中国知网(CNKI)、PubMed和EMBASE关于有机磷农药与再生障碍性贫血发病关系的病例对照研究.制定纳入和排除标准,对符合纳入标准的文献进行质量评价,利用Review Manager 5.0软件计算有机磷农药的合并OR值及其95％CI,并对文献的研究人群和有机磷农药使用方式进行亚组分析.结果 最终共纳入9篇文献,5 833例研究对象,其中病例组1 404人,对照组4 429人.结果显示有机磷农药可增加再生障碍性贫血的发病风险(OR=1.97,95％CI:1.60～ 2.44).亚组分析显示亚洲人群再生障碍性贫血的发病风险(OR=2.01,95％CI:1.52～2.66)高于欧美人群(OR＝1.93,95％CI:1.39 ～ 2.67);使用单一有机磷类农药(OR=2.15,95％CI:1.60 ～ 2.88)比使用有机磷类农药的混配制剂(OR=1.82,95％CI:1.34 ～ 2.47)更易引发再生障碍性贫血.结论 有机磷农药可能是再生障碍性贫血的危险因素.在日常生活和工农业生产中,减少有机磷农药的暴露,可以预防再生障碍性贫血的发生.
目的 評價有機燐農藥與再生障礙性貧血髮病的關繫,為一級預防提供科學依據.方法 檢索1990年1月至2014年8月公開髮錶在中國生物醫學文獻數據庫(CBM)、中國知網(CNKI)、PubMed和EMBASE關于有機燐農藥與再生障礙性貧血髮病關繫的病例對照研究.製定納入和排除標準,對符閤納入標準的文獻進行質量評價,利用Review Manager 5.0軟件計算有機燐農藥的閤併OR值及其95％CI,併對文獻的研究人群和有機燐農藥使用方式進行亞組分析.結果 最終共納入9篇文獻,5 833例研究對象,其中病例組1 404人,對照組4 429人.結果顯示有機燐農藥可增加再生障礙性貧血的髮病風險(OR=1.97,95％CI:1.60～ 2.44).亞組分析顯示亞洲人群再生障礙性貧血的髮病風險(OR=2.01,95％CI:1.52～2.66)高于歐美人群(OR＝1.93,95％CI:1.39 ～ 2.67);使用單一有機燐類農藥(OR=2.15,95％CI:1.60 ～ 2.88)比使用有機燐類農藥的混配製劑(OR=1.82,95％CI:1.34 ～ 2.47)更易引髮再生障礙性貧血.結論 有機燐農藥可能是再生障礙性貧血的危險因素.在日常生活和工農業生產中,減少有機燐農藥的暴露,可以預防再生障礙性貧血的髮生.
목적 평개유궤린농약여재생장애성빈혈발병적관계,위일급예방제공과학의거.방법 검색1990년1월지2014년8월공개발표재중국생물의학문헌수거고(CBM)、중국지망(CNKI)、PubMed화EMBASE관우유궤린농약여재생장애성빈혈발병관계적병례대조연구.제정납입화배제표준,대부합납입표준적문헌진행질량평개,이용Review Manager 5.0연건계산유궤린농약적합병OR치급기95％CI,병대문헌적연구인군화유궤린농약사용방식진행아조분석.결과 최종공납입9편문헌,5 833례연구대상,기중병례조1 404인,대조조4 429인.결과현시유궤린농약가증가재생장애성빈혈적발병풍험(OR=1.97,95％CI:1.60～ 2.44).아조분석현시아주인군재생장애성빈혈적발병풍험(OR=2.01,95％CI:1.52～2.66)고우구미인군(OR＝1.93,95％CI:1.39 ～ 2.67);사용단일유궤린류농약(OR=2.15,95％CI:1.60 ～ 2.88)비사용유궤린류농약적혼배제제(OR=1.82,95％CI:1.34 ～ 2.47)경역인발재생장애성빈혈.결론 유궤린농약가능시재생장애성빈혈적위험인소.재일상생활화공농업생산중,감소유궤린농약적폭로,가이예방재생장애성빈혈적발생.
Objective To evaluate the association between organophosphorus pesticides and aplastic anemia,and provide scientific evidence for the primary prevention of aplastic anemia.Methods The published papers of case control studies on the association between organophosphorus pesticides and aplastic anemia from January 1990 to August 2014 were collected from Chinese BioMedical Literature Base (CBM),Chinese National Knowledge Infrastructure (CNKI),PubMed and EMBASE.The papers which met the inclusion criteria were evaluated.The pooled odds ratios (OR) and 95％ confidence interval (CI) of organophosphorus pesticides were calculated with software Review Manager 5.0.Subgroup analysis were conducted for different population and different usage of organophosphorus pesticides.Results A total of 9 papers were selected,involving 5 833 subjects (1 404 cases and 4 429 controls).The results showed that organophosphorus pesticides could increase the risk of aplastic anemia (OR=1.97,95％ CI:1.60-2.44).Subgroup analysis showed that Asian (OR=2.01,95％CI:1.52-2.66) had higher risk of aplastic anemia than American or European(OR=1.93,95％CI:1.39-2.67).Using pure organophosphorus pesticides (OR=2.15,95％ CI:1.60-2.88) was more prone to cause aplastic anemia than using the mixture of organophosphorus pesticides (OR=1.82,95％ CI:1.34-2.47).Conclusion The analysis indicated that organophosphorus pesticides might be a risk factor for aplastic anemia.Reducing organophosphorus pesticides exposure in daily life and industrial or agricultural production could prevent the incidence of aplastic anemia.
