中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
Chinese Journal of Epidemiology
2015年
9期
958-961
,共4页
曹意%王澄%师雯琦%朱影影%陈耿东%陈裕明
曹意%王澄%師雯琦%硃影影%陳耿東%陳裕明
조의%왕징%사문기%주영영%진경동%진유명
非酒精性脂肪性肝病%患病率%代谢相关因素
非酒精性脂肪性肝病%患病率%代謝相關因素
비주정성지방성간병%환병솔%대사상관인소
Nonalcoholic fatty liver disease%Prevalence%Metabolic factor
目的 探讨非酒精性脂肪性肝病(NAFLD)在中老年人群中的患病情况及其代谢相关因素.方法 采用横断面调查的方法,通过问卷调查和实验室检测对2 935名广州市中老年人进行资料收集、整理.探讨NAFLD在中老年人群中的患病情况,并采用协方差和logistic回归分析代谢因素与NAFLD患病情况之间的关系.NAFLD的诊断标准采用中华医学会肝脏病学分会脂肪肝和酒精性肝病学组的影像学诊断标准,并且按照其严重程度分为轻、中、重三个等级.结果 广州市中老年人群中NAFLD的患病率为50.6％.NAFLD患者组中WC、BMI、FPG、TG、SBP、DBP以及MS患病率均明显高于对照组,而体力活动水平和HDL-C明显降低(P＜0.001).logistic回归分析显示,WC、SBP、DBP、TG、FPG和HDL-C每升高一个标准差其对应NAFLD患病的OR值(95％CI)分别为2.70 (2.45～2.98)、1.47(1.35 ～ 1.59)、1.48(1.37 ～ 1.60)、1.88 (1.66～2.12)、1.25(1.15 ～ 1.36)和0.51 (0.47～0.56).随着NAFLD严重程度不断增加,WC、BMI、TG、SBP、DBP和FPG水平均呈现上升趋势,而HDL-C呈现减少的趋势(P＜0.001).结论 中老年人NAFLD患病率较高,MS及相关组分与NAFLD关系密切,其中WC增加对NAFLD患病影响最大.
目的 探討非酒精性脂肪性肝病(NAFLD)在中老年人群中的患病情況及其代謝相關因素.方法 採用橫斷麵調查的方法,通過問捲調查和實驗室檢測對2 935名廣州市中老年人進行資料收集、整理.探討NAFLD在中老年人群中的患病情況,併採用協方差和logistic迴歸分析代謝因素與NAFLD患病情況之間的關繫.NAFLD的診斷標準採用中華醫學會肝髒病學分會脂肪肝和酒精性肝病學組的影像學診斷標準,併且按照其嚴重程度分為輕、中、重三箇等級.結果 廣州市中老年人群中NAFLD的患病率為50.6％.NAFLD患者組中WC、BMI、FPG、TG、SBP、DBP以及MS患病率均明顯高于對照組,而體力活動水平和HDL-C明顯降低(P＜0.001).logistic迴歸分析顯示,WC、SBP、DBP、TG、FPG和HDL-C每升高一箇標準差其對應NAFLD患病的OR值(95％CI)分彆為2.70 (2.45～2.98)、1.47(1.35 ～ 1.59)、1.48(1.37 ～ 1.60)、1.88 (1.66～2.12)、1.25(1.15 ～ 1.36)和0.51 (0.47～0.56).隨著NAFLD嚴重程度不斷增加,WC、BMI、TG、SBP、DBP和FPG水平均呈現上升趨勢,而HDL-C呈現減少的趨勢(P＜0.001).結論 中老年人NAFLD患病率較高,MS及相關組分與NAFLD關繫密切,其中WC增加對NAFLD患病影響最大.
목적 탐토비주정성지방성간병(NAFLD)재중노년인군중적환병정황급기대사상관인소.방법 채용횡단면조사적방법,통과문권조사화실험실검측대2 935명엄주시중노년인진행자료수집、정리.탐토NAFLD재중노년인군중적환병정황,병채용협방차화logistic회귀분석대사인소여NAFLD환병정황지간적관계.NAFLD적진단표준채용중화의학회간장병학분회지방간화주정성간병학조적영상학진단표준,병차안조기엄중정도분위경、중、중삼개등급.결과 엄주시중노년인군중NAFLD적환병솔위50.6％.NAFLD환자조중WC、BMI、FPG、TG、SBP、DBP이급MS환병솔균명현고우대조조,이체력활동수평화HDL-C명현강저(P＜0.001).logistic회귀분석현시,WC、SBP、DBP、TG、FPG화HDL-C매승고일개표준차기대응NAFLD환병적OR치(95％CI)분별위2.70 (2.45～2.98)、1.47(1.35 ～ 1.59)、1.48(1.37 ～ 1.60)、1.88 (1.66～2.12)、1.25(1.15 ～ 1.36)화0.51 (0.47～0.56).수착NAFLD엄중정도불단증가,WC、BMI、TG、SBP、DBP화FPG수평균정현상승추세,이HDL-C정현감소적추세(P＜0.001).결론 중노년인NAFLD환병솔교고,MS급상관조분여NAFLD관계밀절,기중WC증가대NAFLD환병영향최대.
Objective To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and understand the relationship between NAFLD and metabolic risk factors in middle-aged and elderly adults.Methods This cross-sectional study recruited 2 935 subjects in Guangzhou,Guangdong province.Face-to-face interviews and laboratory analyses were conducted to collect general information and other covariates.Analysis of covariance and logistic regression analysis were performed to investigate the relationship between metabolic factors and the prevalence of NAFLD.NAFLD was diagnosed based on standard criteria recommend by the Fatty Liver Disease and Alcoholic Liver Disease Branch of Chinese Hepatology Society,and the degree of steatosis was assessed (mild,moderate or severe).Results Compared with normal subjects,those with NAFLD had higher levels of WC,BMI,FPG,TG,SBP,DBP and greater prevalence of metabolic syndrome,but lower levels of physical activity and HDL-C.After adjusted for covariates,the OR for each standard deviation change was 2.70(95％CI:2.45-2.98) for WC,1.47(95％ CI:1.35-1.59) for SBP,1.48 (95％CI:1.37-1.60) for DBP,1.88 (95％CI:1.66-2.12) for TG,1.25 (95％ CI:1.15-1.36) for FPG and 0.51 (95％CI:0.47-0.56) for HDL-C (all P＜0.001).Higher levels of WC,BMI,TG,SBP,DBP and FPG were significantly related with the increase in degree of NAFLD (P-trend＜0.001).Conclusion There is a relatively high prevalence of NAFLD in middle-aged and elderly adults in China.NAFLD is closely related with the different forms of metabolic syndrome,and WC is the leading risk factor for NAFLD.
