CAJ | 학술논문

目的：观察原发性肾病综合征(PNS)患者外周血T淋巴细胞亚群的分布变化,探讨T淋巴细胞亚群在PNS发病中的作用。方法收集30例PNS患者的T淋巴细胞亚群数据,根据临床资料将PNS患者分为未用激素组10例和已用激素组20例,同时以26例正常人作为对照组进行比较分析。结果与对照组相比,已用激素组及未用激素组的CD3+、CD3+CD4+均升高,差异均有统计学意义(<0.05)。各组间CD3+(%)、CD3+CD4+(%)、CD3+CD8+(%)均无显著差异。已用激素组和未用激素组的白细胞(WBC)及淋巴细胞(LYM)升高,与对照组比较,差异有统计学意义(<0.05)；未用激素组的辅助T细胞/抑制T细胞(Th/Ts)升高,与对照组比较,差异有统计学意义(<0.05)；已用激素组的Th/Ts也升高,但与对照组比较,差异无统计学意义(＞0.05)。结论 PNS的发病Th细胞增多有关,Th细胞增多导致机体免疫系统功能亢进,从而出现的一系列病理损害。
목적：관찰원발성신병종합정(PNS)환자외주혈T림파세포아군적분포변화,탐토T림파세포아군재PNS발병중적작용。방법수집30례PNS환자적T림파세포아군수거,근거림상자료장PNS환자분위미용격소조10례화이용격소조20례,동시이26례정상인작위대조조진행비교분석。결과여대조조상비,이용격소조급미용격소조적CD3+、CD3+CD4+균승고,차이균유통계학의의(<0.05)。각조간CD3+(%)、CD3+CD4+(%)、CD3+CD8+(%)균무현저차이。이용격소조화미용격소조적백세포(WBC)급림파세포(LYM)승고,여대조조비교,차이유통계학의의(<0.05)；미용격소조적보조T세포/억제T세포(Th/Ts)승고,여대조조비교,차이유통계학의의(<0.05)；이용격소조적Th/Ts야승고,단여대조조비교,차이무통계학의의(＞0.05)。결론 PNS적발병Th세포증다유관,Th세포증다도치궤체면역계통공능항진,종이출현적일계렬병리손해。
Objective To survey the data of T Lymphocyte Subset and research the ef ect of it in initiating Primary Nephrotic Syndrome.Methods Col ected 30 patients with PNS and divided into two groups,not used hormone group of 10 cases,another were used hormone group.In the meantime,26 peoples as matched group to do one way analysis of variance.Results Compared with control group, CD3+,CD3+CD4+were al rose with two groups and <0.05.There were not remarkable dif erences in CD3+(%),CD3+CD4+(%),CD3+CD8+(%)among each groups .Compared with control group, white blood cel s (WBC), lymphocyte (LYM) were al rose with two groups and <0.05. Not with hormone group of helper T cel/suppressor T cel (Th/Ts) was rose, compared with control group, the dif erence was statistical y significant( <0.05).Has been with hormone group Th/Ts also increases,but compared with control group,there was no statistical y significant dif erence ( ﹥0.05).Conclusion CD4+-Th cel s increased lead to the body's immune system function hyperfunction,thus appeared a series of pathological damage.