CAJ | 학술논문

2型糖尿病已经成为严重危害人类健康的全球性疾病，但这并不能完全归因于人类基因组及饮食习惯、生活方式的改变，肠道菌群在糖尿病的发生、发展中也发挥着重要作用。肠道菌群与宿主代谢及免疫之间有着复杂的双向作用，肠道菌群的改变可以导致肥胖、胰岛素抵抗、代谢性内毒素血症、肠道渗透压改变，从而促进糖尿病的发生、发展。而双歧杆菌属作为肠道菌群中一种主要的益生菌，在2型糖尿病的发生、发展中所起的作用不容小视。
2형당뇨병이경성위엄중위해인류건강적전구성질병，단저병불능완전귀인우인류기인조급음식습관、생활방식적개변，장도균군재당뇨병적발생、발전중야발휘착중요작용。장도균군여숙주대사급면역지간유착복잡적쌍향작용，장도균군적개변가이도치비반、이도소저항、대사성내독소혈증、장도삼투압개변，종이촉진당뇨병적발생、발전。이쌍기간균속작위장도균군중일충주요적익생균，재2형당뇨병적발생、발전중소기적작용불용소시。
Type 2 diabetes has become a global disease endangering human health seriously. Various studies have shown that this phenomenon could not be completely attributed to the changes in the human genome,nutritional habits,and lifestyle,since the intestinal flora also plays an important role. The gut micro-flora has complex and bidirectional relationship with host metabolism and immune function,altered gut micro-flora cause increased adiposity,insulin resistance,metabolic endotoxemia,and intestinal permeability,which then promotes the occurrence and development of type 2 diabetes. As one of the major probiotics,bifidobacte-rium is of great importance in the development of type 2 diabetes.