医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
17期
3180-3183
,共4页
高雨梅(综述)%康文娟(审校)
高雨梅(綜述)%康文娟(審校)
고우매(종술)%강문연(심교)
2型糖尿病%糖尿病肾病%血脂异常
2型糖尿病%糖尿病腎病%血脂異常
2형당뇨병%당뇨병신병%혈지이상
Type 2 diabetes mellitus%Diabetic nephropathy%Dyslipoproteinemia
脂代谢紊乱在2型糖尿病和慢性肾脏疾病中有很高的患病率。血清高三酰甘油、高胆固醇可直接作用于肾小球血管内皮细胞、肾小球系膜细胞、肾小管细胞而损害肾脏；还可通过血清高胰岛素影响血管紧张素Ⅱ合成，使单核细胞和肾小球系膜细胞分泌转化生长因子β和肿瘤坏死因子α及其他炎性因子而间接损伤肾脏。及时检测糖尿病患者血脂蛋白水平有着重要的意义。
脂代謝紊亂在2型糖尿病和慢性腎髒疾病中有很高的患病率。血清高三酰甘油、高膽固醇可直接作用于腎小毬血管內皮細胞、腎小毬繫膜細胞、腎小管細胞而損害腎髒；還可通過血清高胰島素影響血管緊張素Ⅱ閤成，使單覈細胞和腎小毬繫膜細胞分泌轉化生長因子β和腫瘤壞死因子α及其他炎性因子而間接損傷腎髒。及時檢測糖尿病患者血脂蛋白水平有著重要的意義。
지대사문란재2형당뇨병화만성신장질병중유흔고적환병솔。혈청고삼선감유、고담고순가직접작용우신소구혈관내피세포、신소구계막세포、신소관세포이손해신장；환가통과혈청고이도소영향혈관긴장소Ⅱ합성，사단핵세포화신소구계막세포분비전화생장인자β화종류배사인자α급기타염성인자이간접손상신장。급시검측당뇨병환자혈지단백수평유착중요적의의。
Dyslipoproteinemia is highly prevalent in type 2 diabetes mellitus and chronic kidney disease. High triglycerides and high cholesterol in serum may directly damage the kidneys by acting on glomerular endothelial cells,mesangial cells and renal tubular cells;in addition they can indirectly damage the kidneys by affecting angiotensinⅡsynthesizing through high serum insulin,and secreting of tranforming growth factorβ,tumor necrosis factor α and other inflammatory cytokines from monocytes and glomerular mesangial cells. Timely examination of serum lipoprotein levels in patients with diabetes is very important.
