CAJ | 학술논문

糖尿病心肌病是糖尿病最主要的独立并发症之一，越来越多的证据表明，糖尿病时活性氧类( ROS)产生增多，氧化应激反应增强是导致糖尿病心肌病的最主要原因之一。抗氧化剂可抑制ROS的产生，增强抗氧化防御系统清除能力，抑制氧化应激对心肌的损伤，从而发挥对心肌的保护作用，是延缓糖尿病心肌病发生和发展最有潜力的治疗策略。
당뇨병심기병시당뇨병최주요적독립병발증지일，월래월다적증거표명，당뇨병시활성양류( ROS)산생증다，양화응격반응증강시도치당뇨병심기병적최주요원인지일。항양화제가억제ROS적산생，증강항양화방어계통청제능력，억제양화응격대심기적손상，종이발휘대심기적보호작용，시연완당뇨병심기병발생화발전최유잠력적치료책략。
The diabetic cardiomyopathy is one of the independent diabetic mellitus complications. There is growing evidence that diabetes increases production of reactive oxygen species(ROS),and enhanced oxi-dative stress is one of the main causes of diabetic cardiomyopathy. Antioxidants can inhibit the generation of ROS,and enhance clearing ability of the antioxidant defense system,and then inhibit oxidative stress caused myocardial injury,so as to achieve the protective effect on the myocardium,which is the most promising thera-peutic strategy to delay the development of diabetic cardiomyopathy.