医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
17期
3160-3162
,共3页
郑亚如%叶利方(综述)%王利宏(审校)
鄭亞如%葉利方(綜述)%王利宏(審校)
정아여%협리방(종술)%왕리굉(심교)
心房颤动%脑卒中预防%华法林%抗凝治疗
心房顫動%腦卒中預防%華法林%抗凝治療
심방전동%뇌졸중예방%화법림%항응치료
Atrial fibrillation%Stroke prevention%Warfarin%Anticoagulation treatment
心房颤动(房颤)和慢性肾病发病率都随着年龄的增长而增高,房颤合并慢性肾病患者脑卒中和出血风险增加。抗凝治疗可以降低房颤患者脑卒中发生率,华法林是临床上房颤患者最常用的抗凝药物,但目前房颤合并终末期肾病患者从华法林治疗中获益的报道较少见。新型口服抗凝药与华法林在房颤抗凝中同样有效,且更加安全、有效、容易管理。目前房颤合并肾病抗凝治疗的观点仍存在争议。
心房顫動(房顫)和慢性腎病髮病率都隨著年齡的增長而增高,房顫閤併慢性腎病患者腦卒中和齣血風險增加。抗凝治療可以降低房顫患者腦卒中髮生率,華法林是臨床上房顫患者最常用的抗凝藥物,但目前房顫閤併終末期腎病患者從華法林治療中穫益的報道較少見。新型口服抗凝藥與華法林在房顫抗凝中同樣有效,且更加安全、有效、容易管理。目前房顫閤併腎病抗凝治療的觀點仍存在爭議。
심방전동(방전)화만성신병발병솔도수착년령적증장이증고,방전합병만성신병환자뇌졸중화출혈풍험증가。항응치료가이강저방전환자뇌졸중발생솔,화법림시림상상방전환자최상용적항응약물,단목전방전합병종말기신병환자종화법림치료중획익적보도교소견。신형구복항응약여화법림재방전항응중동양유효,차경가안전、유효、용역관리。목전방전합병신병항응치료적관점잉존재쟁의。
Incidence of chronic kidney disease ( CKD ) and atrial fibrillation ( AF ) generally increase with age. Patients with AF combined with CKD are at increased risk of both stroke and bleeding events. Anti-coagulation treatment has been shown to reduce the risk of stroke. Warfarin is the most commonly used antico-agulant drugs in AF patients,while until now few studies indicated that patients with end-stage renal disease could benefit from warfarin therapy. The novel oral anticoagulants was shown non-inferior and more effective, safer and easier to administer compared to warfarin. There is controversy on the benefits of anticoagulation in patients with AF combined with renal diseases.