CAJ | 학술논문

目的：利用生物学变异建立差值显著性评价方法，并用于检验结果评价。方法通过室内质量控制数据获得贝克曼 AU68全自动生化仪的累计在控变异系数，结合个体内生物学变异计算肝肾功能和电解质等12项生化项目的参考变化值，并评价慢性肾炎患者连续监测的检验结果。结果仪器的分析变异相对固定，总的分析变异与个体内生物学变异相关。差值显著性计算后慢性肾炎患者治疗3个月时的总蛋白、清蛋白、丙氨酸氨基转移酶和肌酐有显著性改变；治疗后8个月肾功能的指标变化没有显著性。结论临床实验室可以使用差值显著性评价方法对患者检验结果和监测指标的系列结果变化进行评价，帮助临床医生科学解读检验报告。
목적：이용생물학변이건립차치현저성평개방법，병용우검험결과평개。방법통과실내질량공제수거획득패극만 AU68전자동생화의적루계재공변이계수，결합개체내생물학변이계산간신공능화전해질등12항생화항목적삼고변화치，병평개만성신염환자련속감측적검험결과。결과의기적분석변이상대고정，총적분석변이여개체내생물학변이상관。차치현저성계산후만성신염환자치료3개월시적총단백、청단백、병안산안기전이매화기항유현저성개변；치료후8개월신공능적지표변화몰유현저성。결론림상실험실가이사용차치현저성평개방법대환자검험결과화감측지표적계렬결과변화진행평개，방조림상의생과학해독검험보고。
Objective To establish the difference significant evaluation method by using the biological variation and to apply it in the testing results evaluation .Methods The accumulated controlling variation coefficient of the Beckman AU680 automatic biochemical analyzer was obtained by the internal quality control data ,the reference change values(RCV) of 12 biochemical items of hepatorenal function and electrolytes were calculated by combining with the individual biological variation .Then series testing results of a chronic nephritis patient were evaluated .Re‐sults The anatyical variation of the instrument was relatively stable .The total analytical variation was correlated with the individual biological variation .After difference value significant calculation ,the results of TP ,ALB ,ALT and CREA in the chronic nephritis patient were changed significantly after 3 months treatment ;the change of renal func‐tion indexes after 8 - month treatment had no significance .Conclusion Clinical laboratories can apply the RCV meth‐od and the significance probability to evaluate the changes in the detection results and the series results change of mo‐nitoring indexes for helping clinical doctors to interpreting the testing report .