检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
19期
2859-2860,2862
,共3页
急性心肌梗死%rtPA%静脉溶栓%血管再通率
急性心肌梗死%rtPA%靜脈溶栓%血管再通率
급성심기경사%rtPA%정맥용전%혈관재통솔
acute myocardial infarction%rtPA%venous thrombolytic%recanalization rate
目的：探讨半剂量和全剂量重组人组织型纤溶酶原激活物（rtPA）溶栓药物爱通立治疗急性 ST 段抬高型心肌梗死（STEMI）的疗效。方法将216例 STEMI 患者根据给药方法不同分为半剂量组（n＝118）和全剂量组（n＝98），观察两组患者的冠状动脉血管再通率、出血不良反应、明显心律失常发生率。结果治疗后，半剂量组和全剂量组血管再通率分别78．4％（92／118）、83．3％（81／98），差异有统计学意义（P ＜0．05）。两组出血不良反应及明显心律失常发生率差异无统计学意义（P＞0．05）。 STEMI 发病后3 h 内、3～6 h 、＞6～12 h 给予 rtPA 溶栓治疗的患者血管再通率分别为91．2％、73．9％、53．80％。结论 rtPA 治疗 STEMI 的疗效肯定，安全可靠，尤其适用于无条件进行介入治疗的基层医院。
目的：探討半劑量和全劑量重組人組織型纖溶酶原激活物（rtPA）溶栓藥物愛通立治療急性 ST 段抬高型心肌梗死（STEMI）的療效。方法將216例 STEMI 患者根據給藥方法不同分為半劑量組（n＝118）和全劑量組（n＝98），觀察兩組患者的冠狀動脈血管再通率、齣血不良反應、明顯心律失常髮生率。結果治療後，半劑量組和全劑量組血管再通率分彆78．4％（92／118）、83．3％（81／98），差異有統計學意義（P ＜0．05）。兩組齣血不良反應及明顯心律失常髮生率差異無統計學意義（P＞0．05）。 STEMI 髮病後3 h 內、3～6 h 、＞6～12 h 給予 rtPA 溶栓治療的患者血管再通率分彆為91．2％、73．9％、53．80％。結論 rtPA 治療 STEMI 的療效肯定，安全可靠，尤其適用于無條件進行介入治療的基層醫院。
목적：탐토반제량화전제량중조인조직형섬용매원격활물（rtPA）용전약물애통립치료급성 ST 단태고형심기경사（STEMI）적료효。방법장216례 STEMI 환자근거급약방법불동분위반제량조（n＝118）화전제량조（n＝98），관찰량조환자적관상동맥혈관재통솔、출혈불량반응、명현심률실상발생솔。결과치료후，반제량조화전제량조혈관재통솔분별78．4％（92／118）、83．3％（81／98），차이유통계학의의（P ＜0．05）。량조출혈불량반응급명현심률실상발생솔차이무통계학의의（P＞0．05）。 STEMI 발병후3 h 내、3～6 h 、＞6～12 h 급여 rtPA 용전치료적환자혈관재통솔분별위91．2％、73．9％、53．80％。결론 rtPA 치료 STEMI 적료효긍정，안전가고，우기괄용우무조건진행개입치료적기층의원。
Objective To investigate the effect of half dose and full dose of alteplase as human recombinant tissue type profibrinolysin activator(rtPA) thrombolytic drug in treating ST‐segment elevation myocardial infarction (STEMI) .Methods 216 cases of STEMI were divided into the half dose group(n= 118) and the full dose group(n=98) according to the administration methods .The coronary artery recanalization rate ,bleeding adverse reaction and occurrence rate of obvious arrhythmia were observed and compared between the two groups .Results The coronary artery recanalization rates after treatment in the half dose group and the full dose group were 78 .4 % (92/118) and 83 .3% (81/98) respectively ,and the difference was statistically significant (P < 0 .05) .But the occurrence rates of bleeding and obvious arrhythmia had no statistical difference between the two groups(P> 0 .05) .The rates of coro‐nary artery recanalization in the patients treated by the rtPA thrombolytic treatment within 3 ,3 - 6 ,> 6 - 12 h after STEMI onset were 91 .2% ,73 .9% and 53 .80% respectively .Conclusion The rtPA therapy is effective ,safe and re‐liable for treating STEMI ,especially suitable for the primary hospital without condition for conducting intervention treatment .
