CAJ | 학술논문

纳洛酮为阿片受体拮抗剂，能竞争拮抗应激状态下大量阿片肽(内啡肽、强啡肽、脑啡肽)产生的病理生理效应，如抑制呼吸、支气管痉挛、血压下降、心脑缺氧缺血等，在临床上用于阿片类药物急性中毒的解毒及其依赖患者的诊断和治疗。近年来，随着对其药理研究的不断深入，其应用领域也不断拓展，尤其在抢救危急重症患者时应用广泛，现将纳洛酮在临床中的应用情况综述如下。
납락동위아편수체길항제，능경쟁길항응격상태하대량아편태(내배태、강배태、뇌배태)산생적병리생리효응，여억제호흡、지기관경련、혈압하강、심뇌결양결혈등，재림상상용우아편류약물급성중독적해독급기의뢰환자적진단화치료。근년래，수착대기약리연구적불단심입，기응용영역야불단탁전，우기재창구위급중증환자시응용엄범，현장납락동재림상중적응용정황종술여하。
Naloxone for opioid receptor antagonist, competition can adersely affect the stress state of opioid peptide (endorphin, dyna, enkephalin) produces pathological physiological effects, such as inhibition of respiration, bronchospasm, drop in blood pressure and cardio-cerebral hypoxia ischemia, clinically used for opioid detoxification of acute poisoning and depend on the patient's diagnosis and treatment. In recent years, with the deepening of the research of its pharmacological, also continue to expand its application fields, especially widely used in rescuing patients with emergency and severe cases, will now naloxone in clinical application were reviewed as follows.