CAJ | 학술논문

目的：探讨苦杏仁苷对老年糜烂性胃炎患者血清超氧化物歧化酶（SOD）、丙二醛（MDA）和一氧化氮（NO）浓度的影响。方法选取老年糜烂性胃炎患者120例，随机分为对照组和实验组，每组60例，其中对照组给予奥美拉唑和胶体果胶铋常规治疗，实验组在对照组的基础上，给予口服苦杏仁苷0．5 g ，1次／日。比较两组患者的临床疗效，内镜下糜烂愈合程度，血清 SOD 、MDA 及 NO 浓度变化。结果治疗后，实验组疗效明显优于对照组（P＜0．05）；实验组内镜下愈合程度明显优于对照组（P＜0．05）；实验组 SOD 浓度高于对照组，MDA 、NO 浓度低于对照组，差异有统计学意义（P＜0．05）。结论苦杏仁苷能够改善老年糜烂性胃炎患者的临床疗效，加快糜烂的愈合，其作用机制可能与血清 SOD 、MDA 和 NO 有关。
목적：탐토고행인감대노년미란성위염환자혈청초양화물기화매（SOD）、병이철（MDA）화일양화담（NO）농도적영향。방법선취노년미란성위염환자120례，수궤분위대조조화실험조，매조60례，기중대조조급여오미랍서화효체과효필상규치료，실험조재대조조적기출상，급여구복고행인감0．5 g ，1차／일。비교량조환자적림상료효，내경하미란유합정도，혈청 SOD 、MDA 급 NO 농도변화。결과치료후，실험조료효명현우우대조조（P＜0．05）；실험조내경하유합정도명현우우대조조（P＜0．05）；실험조 SOD 농도고우대조조，MDA 、NO 농도저우대조조，차이유통계학의의（P＜0．05）。결론고행인감능구개선노년미란성위염환자적림상료효，가쾌미란적유합，기작용궤제가능여혈청 SOD 、MDA 화 NO 유관。
Objective To investigate the effect of amygdalin on serum SOD ,MDA and NO levels in elderly e‐rosive gastritis patients .Methods 120 elderly patients with erosive gastritis were selected and randomly divided into the control group and the experimental group ,60 cases in each group .The control group was given the routine treat‐ment of omeprazole and colloidal bismuth pectin ,while on this basis the experimental group was given oral amygdalin 0 .5 g ,once daily .The clinical effects ,endoscopic erosion healing degree and changes of serum SOD ,MDA and NO levels were compared between the two groups .Results The clinical efficacy after treatment in the experimental group was significantly superior to that in the control group ,the difference was statistically significant(P< 0 .05) ;the gastroscopic erosive healing level in the experimental group was significantly better than that in the control group ,the difference was statistically significant (P < 0 .05) ;serum SOD level after treatment in the experimental group was higher than that in the control group ,while serum MDA and NO levels were lower than those in the control group , the differences were statistically significant (P < 0 .05) .Conclusion Amygdalin can improve the clinical efficacy in elderly patients with erosive gastritis and accelerates the erosion healing ,its mechanism may be related with serum SOD ,MDA and NO .