CAJ | 학술논문

目的：探讨氟桂利嗪治疗癫合并偏头痛患者的临床疗效及安全性。方法选取2013年1月至2015年2月黑龙江省医院收治的癫共患偏头痛患者50例作为研究对象，将其完全随机均分为两组，对照组患者应用抗癫药物治疗，观察组患者在对照组治疗基础上联合氟桂利嗪进行治疗。比较两组患者治疗1年后的临床效果、用药后的不良反应，以此分析用药安全性。结果观察组患者对病情控制有效率明显优于对照组，差异有统计学意义（P＜0.05）。治疗1年后观察组患者出现不良反应2例，对照组出现不良反应4例，差异无统计学意义（P＞0.05）。结论癫合并偏头痛患者应用抗癫药物治疗时，联合小剂量氟桂利嗪可有效控制病情，疗效极佳，但有少量不良反应出现。
목적：탐토불계리진치료전합병편두통환자적림상료효급안전성。방법선취2013년1월지2015년2월흑룡강성의원수치적전공환편두통환자50례작위연구대상，장기완전수궤균분위량조，대조조환자응용항전약물치료，관찰조환자재대조조치료기출상연합불계리진진행치료。비교량조환자치료1년후적림상효과、용약후적불량반응，이차분석용약안전성。결과관찰조환자대병정공제유효솔명현우우대조조，차이유통계학의의（P＜0.05）。치료1년후관찰조환자출현불량반응2례，대조조출현불량반응4례，차이무통계학의의（P＞0.05）。결론전합병편두통환자응용항전약물치료시，연합소제량불계리진가유효공제병정，료효겁가，단유소량불량반응출현。
Objective To investigate the treatment of epilepsy Flunarizine comorbid migraine sufferers clinical effect and safety.Methods January 2013 to February 2015 in Heilongjiang Province admitted to hospital were suffering from epilepsy migraine patients was observed in 50 patients for the study,which was completely randomly divided into two groups,a control group of patients with anti-epileptic drugs,in the control group on the basis of joint flunarizine treatment.Comparison of the clinical effect of two groups of patients after 1 year,adverse reactions after treatment,in order to analyze drug safety.Results The observation group were effective control of the disease than the control group,the difference was statisticaly significant(P<0.05).Treatment observation group of patients 1 year after two cases of adverse reactions,the control group had four cases of adverse reactions,the difference was not statisticaly significant(P>0.05).Conclusion Epilepsy patients were suffering from migraine antiepileptic drug treatment,in combination with low-dose flunarizine can effectively control the disease,excelent efficacy,but there are a few adverse reactions.