CAJ | 학술논문

近年来，随着化疗的大量开展，继发性白血病发病率逐年升高，笔者报道1例卵巢癌并发乳腺癌患者经化疗、放疗后出现急性粒-单细胞白血病，从初次化疗至诊断急性白血病的时间为37个月，起病急、生存期短。文献报道烷化剂、拓扑异构酶I抑制剂、铂类均易诱发继发性白血病。造血干细胞移植可降低病死率、延长无进展生存期。
근년래，수착화료적대량개전，계발성백혈병발병솔축년승고，필자보도1례란소암병발유선암환자경화료、방료후출현급성립-단세포백혈병，종초차화료지진단급성백혈병적시간위37개월，기병급、생존기단。문헌보도완화제、탁복이구매I억제제、박류균역유발계발성백혈병。조혈간세포이식가강저병사솔、연장무진전생존기。
In recent years ,with a large number of chemotherapy development ,the incidence of secondary leukemia in-creased year by year ,an acute myelomonocytic leukemia after chemotherapy and radiotherapy in 1 case of ovarian cancer and breast cancer was reported .The time from first chemotherapy to acute leukemia onset was 37 months .This patient had rapid onset and short survival period .Reports in the literature suggested that alkylating agents ,topoisomerase I inhibitors ,platinum were all easy to induce secondary leukemia .Hematopoietic stem cell transplantation coud reduce mortality and prolong progres-sion free survival .