CAJ | 학술논문

目的：观察腺苷蛋氨酸治疗慢性乙型肝炎伴胆红素升高的临床疗效及安全性。方法符合诊断标准的69例患者随机分为治疗组34例与对照组35例。治疗组采用注射用丁二磺酸腺苷蛋氨酸治疗，对照组采用苦黄注射液治疗，4周为1个疗程，比较两组疗效及安全性。结果治疗组总有效率为91．2％，疗效明显优于对照组的68.6％（ P＜0．05），且治疗后治疗组血清ALT、血清胆红素、TBA等肝功能指标改善程度明显优于对照组（P＜0．01）；治疗组未发生药品不良反应，对照组发生3例药品不良反应。结论腺苷蛋氨酸治疗慢性乙型肝炎伴胆红素升高临床疗效及安全性优于苦黄。
목적：관찰선감단안산치료만성을형간염반담홍소승고적림상료효급안전성。방법부합진단표준적69례환자수궤분위치료조34례여대조조35례。치료조채용주사용정이광산선감단안산치료，대조조채용고황주사액치료，4주위1개료정，비교량조료효급안전성。결과치료조총유효솔위91．2％，료효명현우우대조조적68.6％（ P＜0．05），차치료후치료조혈청ALT、혈청담홍소、TBA등간공능지표개선정도명현우우대조조（P＜0．01）；치료조미발생약품불량반응，대조조발생3례약품불량반응。결론선감단안산치료만성을형간염반담홍소승고림상료효급안전성우우고황。
Objective To evaluate the clinical efficiencies and safeties of S-adenosylmethionine (SAM ) in treatment of 34 patients with chronic hepatitis B complicated hyperbilirubinemia .Methods Patients which meet the diagnostic criteria were randomized into the group with treatment of SAM (the treatment group ,34 cases) and the group with Kuhuang injection (the contrast group ,35 cases) ,4 weeks for a course of treatment .The clinical efficacies and safeties were observed in the two groups .Results Compared with the contrast group ,the overall efficiency was better in the treatment group (91 .2% vs 68.6% , P<0 .05) ,and the curative effects of serum ALT ,serum bilirubin ,TBA levels were better in the treatment group after treatment (P<0 .01) .There were no adverse drug reactions in the treatment group and 3 cases with adverse drug reactions in the contrast group .Conclusion The clinical efficiencies and safeties of SAM treatment in patients with chronic hepatitis B com-plicated hyperbilirubinemia were better than that of Kuhuang injection .