CAJ | 학술논문

目的：建立常用药物辅料（甘油）中有毒掺杂物（二甘醇）的快速检测方法。方法利用拉曼／近红外光谱法结合移动窗口相关系数法评价有毒掺杂物的检测灵敏度。结果拉曼光谱下获得的检测灵敏度优于近红外光谱，同时移动窗口法可进一步提高检测灵敏度。结论拉曼光谱法有望成为现场快速检测药物辅料中掺杂有毒物质的有效方法。
목적：건립상용약물보료（감유）중유독참잡물（이감순）적쾌속검측방법。방법이용랍만／근홍외광보법결합이동창구상관계수법평개유독참잡물적검측령민도。결과랍만광보하획득적검측령민도우우근홍외광보，동시이동창구법가진일보제고검측령민도。결론랍만광보법유망성위현장쾌속검측약물보료중참잡유독물질적유효방법。
Objective To develop a rapid method for the detection of toxic adulterant (diethylene glycol) in pharmaceuti-cal excipient (glycerol) .Method The detection sensitivity of Raman/near infrared (NIR) spectroscopy combined with moving window correlation coefficient (MWCC) method was evaluated .Results The detection sensitivity of Raman spectroscopy was superior to that of NIR spectroscopy and with the assistance of MWCC method ;the sensitivity had been further improved . Conclusion Raman spectroscopy has the potential to become the effective method in the on-site detection of toxic adulterant in pharmaceutical excipient .