CAJ | 학술논문

脑转移性肿瘤是成人最常见的颅内恶性肿瘤，治疗手段有限，传统的治疗方法主要以放射治疗为主。替莫唑胺是新一代的烷化剂，具有透过血脑屏障起到抗肿瘤的作用，在脑胶质瘤的治疗上应用广泛，疗效确切。近年来尝试在脑转移性肿瘤上使用替莫唑胺治疗亦得到肯定疗效，替莫唑胺与其他化疗药物或放疗联合可能有助于控制肿瘤，使患者得到生存获益。本文就国内外使用替莫唑胺治疗脑转移瘤的现状进展进行综述。
뇌전이성종류시성인최상견적로내악성종류，치료수단유한，전통적치료방법주요이방사치료위주。체막서알시신일대적완화제，구유투과혈뇌병장기도항종류적작용，재뇌효질류적치료상응용엄범，료효학절。근년래상시재뇌전이성종류상사용체막서알치료역득도긍정료효，체막서알여기타화료약물혹방료연합가능유조우공제종류，사환자득도생존획익。본문취국내외사용체막서알치료뇌전이류적현상진전진행종술。
Brain metastases are most common intracranial malignant tumors in adults, with the progress of tumor treatment means, the better curative effect of malignant tumor and the longer survival time, the incidence of brain metastases increase. That will be serious impact on quality of life. Treatment of brain metastases is limited, radiation therapy is the traditional one. As a new generation of alkylating agent temozolomide, which show antitumor effects by through the blood-brain barrier, widely used in the treatment of glioma. In recent years attempts to using temozolomide therapy metastatic cancer also effective. This paper summarize using temozolomide in the treatment of brain metastases.