中国临床医学
中國臨床醫學
중국림상의학
Chinese Journal of Clinical Medicine
2015年
4期
536-538
,共3页
腹膜透析%脂联素%C 反应蛋白%炎性反应
腹膜透析%脂聯素%C 反應蛋白%炎性反應
복막투석%지련소%C 반응단백%염성반응
Peritoneal dialysis%Adiponectin%C reactive protein%Inflammation
目的：：探讨腹膜透析患者的血清脂联素(adiponectin,ADPN)水平与动脉粥样硬化和炎性反应状态的关系。方法：选择48例病情稳定的腹膜透析患者,检测血清 C 反应蛋白(CRP)、ADPN 等指标及动脉粥样硬化情况,分析各因素之间的相关性。结果：与非动脉粥样硬化组相比,动脉粥样硬化组 ADPN 水平显著降低(P <0.01),而 CRP 水平显著升高(P <0.01)；高 CRP组血清 ADPN 水平明显低于正常 CRP 组(P <0.01)；Pearson 相关分析显示 CRP 与 ADPN 呈负相关(P <0.01)。结论：腹膜透析患者的 ADPN 水平低下可加剧炎性反应状态,从而促进动脉粥样硬化。
目的：：探討腹膜透析患者的血清脂聯素(adiponectin,ADPN)水平與動脈粥樣硬化和炎性反應狀態的關繫。方法：選擇48例病情穩定的腹膜透析患者,檢測血清 C 反應蛋白(CRP)、ADPN 等指標及動脈粥樣硬化情況,分析各因素之間的相關性。結果：與非動脈粥樣硬化組相比,動脈粥樣硬化組 ADPN 水平顯著降低(P <0.01),而 CRP 水平顯著升高(P <0.01)；高 CRP組血清 ADPN 水平明顯低于正常 CRP 組(P <0.01)；Pearson 相關分析顯示 CRP 與 ADPN 呈負相關(P <0.01)。結論：腹膜透析患者的 ADPN 水平低下可加劇炎性反應狀態,從而促進動脈粥樣硬化。
목적：：탐토복막투석환자적혈청지련소(adiponectin,ADPN)수평여동맥죽양경화화염성반응상태적관계。방법：선택48례병정은정적복막투석환자,검측혈청 C 반응단백(CRP)、ADPN 등지표급동맥죽양경화정황,분석각인소지간적상관성。결과：여비동맥죽양경화조상비,동맥죽양경화조 ADPN 수평현저강저(P <0.01),이 CRP 수평현저승고(P <0.01)；고 CRP조혈청 ADPN 수평명현저우정상 CRP 조(P <0.01)；Pearson 상관분석현시 CRP 여 ADPN 정부상관(P <0.01)。결론：복막투석환자적 ADPN 수평저하가가극염성반응상태,종이촉진동맥죽양경화。
Objective:To investigate the relationship between arteriosclerosis and inflammatory status and adiponectin (ADPN) in peritoneal dialysis patients.Methods:A total of 48 stable peritoneal dialysis patients were enrolled,and C reactive protein (CRP)and ADPN in the serum were measured.Arteriosclerosis (AS)was detected by vascular ultrasound.Then the relation-ships between them were analyzed.Results:Compared with the no-AS group,the AS group had significant lower level of AD-PN (P <0.01)and significant higher level of CRP (P <0.01).The level of ADPN was lower in the high CRP group than that in the normal CRP (P <0.01).Pearson correlation analysis showed that CRP had a significant negative correlation with ADPN (P <0.01).Conclusions:Low serum ADPN level in peritoneal dialysis patients can aggravate inflammatory staus,and promote arteriosclerosis.
