CAJ | 학술논문

目的：：评价补充维生素 D 对前列腺癌患者病死率及不良反应发生率的影响。方法：用计算机检索 PubMed、The Co-chrane Library、CNKI、万方数据库和维普数据库,检索时限均为从建库至2014年4月,同时手动检索(手检)相关杂志,查找比较维生素 D 和安慰剂治疗前列腺癌的随机对照试验(RCT)。由2名研究者按纳入与排除标准独立筛选文献,提取资料和评价质量后采用 RevMan5.2软件进行统计分析。结果：共纳入3篇随机对照试验,共计2243例患者。Meta 分析结果显示,维生素 D 能降低前列腺癌病死率[OR=0.23,95%CI ：0.18~0.29],不良事件未见报道。结论：维生素 D 能降低前列腺癌的病死率。但该分析为二次研究,纳入的原始文献质量不一,而且评价过程也可能存在偏倚,故上述结论尚需进一步开展大规模的基础和临床研究来验证。
목적：：평개보충유생소 D 대전렬선암환자병사솔급불량반응발생솔적영향。방법：용계산궤검색 PubMed、The Co-chrane Library、CNKI、만방수거고화유보수거고,검색시한균위종건고지2014년4월,동시수동검색(수검)상관잡지,사조비교유생소 D 화안위제치료전렬선암적수궤대조시험(RCT)。유2명연구자안납입여배제표준독립사선문헌,제취자료화평개질량후채용 RevMan5.2연건진행통계분석。결과：공납입3편수궤대조시험,공계2243례환자。Meta 분석결과현시,유생소 D 능강저전렬선암병사솔[OR=0.23,95%CI ：0.18~0.29],불량사건미견보도。결론：유생소 D 능강저전렬선암적병사솔。단해분석위이차연구,납입적원시문헌질량불일,이차평개과정야가능존재편의,고상술결론상수진일보개전대규모적기출화림상연구래험증。
Objective:To evaluate the effects of vitamin D supplement on the mortality and incidence rate of adverse events of prostate cancer.Methods:Date from PubMed,The Cochrane Library,CNKI,Wanfang Data and VIP database during the date of database establishment and April 2014 were searched online,while relevant journals were searched manually,for all rando-mized controlled trials (RCTs)of comparison between vitamin D and placebo in the treatment of prostate cancer.The data ex-traction and quality assessment were conducted according to inclusion and exclusion criteria by two reviewers independently with RevMan5.2.Results:A total of 3 RCTs involving 2243 cases met the inclusion criteria.Vitamin D could reduce the mor-tality of prostate cancer[OR=0.23,95%CI:0.1 8-0.29],as meta-analysis demonstrated.There was no report on adverse e-vents.Conclusions:Vitamin D could reduce the mortality of prostate cancer.However,the analysis is secondary study,of which the included literatures differ in quality,and there may be bias in analytical process.Thus,basic and clinical researches with large-scale and high-quality should be performed to confirm the above conclusion.