CAJ | 학술논문

目前，从海洋生物中寻找活性物质，是研究开发天然药物的一个重要方向。乌贼是丰富易得的海洋生物，而乌贼墨是乌贼加工中的废弃物，它作为一种极具潜力的海洋活性物质，具有止血、抗菌、增强免疫、抗肿瘤、抗氧化等多种生理活性。乌贼墨多糖就是从乌贼墨中分离出的一种主要活性成分，在抗氧化、抗肿瘤、抗化疗、增强免疫等功能活性方面均表现出了良好的作用效果。通过对乌贼墨中生物活性成分的研究，不仅为乌贼加工废弃物提供了高值化利用途径，也为开发临床医药、保健食品提供了新的资源，对扩大药源及对海洋资源的充分利用都具有深远意义，已受到科研工作者的广泛关注。本文通过综合近年来国内外有关乌贼墨及其活性多糖的研究进展，对它们的理化性质、生物活性和临床应用等方面进行了较为系统的综述，并根据其研究特点和应用前景提出了未来研究的发展方向。
목전，종해양생물중심조활성물질，시연구개발천연약물적일개중요방향。오적시봉부역득적해양생물，이오적묵시오적가공중적폐기물，타작위일충겁구잠력적해양활성물질，구유지혈、항균、증강면역、항종류、항양화등다충생리활성。오적묵다당취시종오적묵중분리출적일충주요활성성분，재항양화、항종류、항화료、증강면역등공능활성방면균표현출료량호적작용효과。통과대오적묵중생물활성성분적연구，불부위오적가공폐기물제공료고치화이용도경，야위개발림상의약、보건식품제공료신적자원，대확대약원급대해양자원적충분이용도구유심원의의，이수도과연공작자적엄범관주。본문통과종합근년래국내외유관오적묵급기활성다당적연구진전，대타문적이화성질、생물활성화림상응용등방면진행료교위계통적종술，병근거기연구특점화응용전경제출료미래연구적발전방향。
ABSTRACT:At present, it is an important way to study the development of natural medicine via searching for active substances from marine life. Squid is an abundant marine animal and its ink is wastes from squid processing. However, Squid ink is a kind of marine active substance with great potential on its physiological activities, such as hemostasis, antibacterial, enhance immunity, antitumor and antioxidation. Squid ink polysaccharide is the most important active ingredient isolated from squid ink, which has good effects of antioxidant, antitumor, antichemotherapy and enhanced immunity, etc. The researches on bioactive constituents in squid ink provide not only high value utilization way for squid processing wastes, but also new resources for development of clinical medicine and health food, which demonstrate great significance to expand the source of medicine and make full use of marine resources, thus, attract the extensive attention from scientific researchers. In this review, we summarized the recent research progress about squid ink and its polysaccharide at home and abroad, in terms of their physical and chemical properties, biological activity and clinical application, and proposed the future research direction according to their research characteristic and application prospects.