CAJ | 학술논문

蕨麻是蔷薇科委陵菜属植物鹅绒委陵菜(Potentilla anserine L.)的根，主要分布于北半球的温带、寒带和高寒地区，在我国主要分布于青海、西藏等地。蕨麻主要含有甾类、三萜类、黄酮类、酚酸类和香豆素类化合物等多种化学成分。中医学研究表明，蕨麻具有健胃补脾、生津解渴、益气补血等功能。生物活性研究结果显示，蕨麻提取物具有耐缺氧、抗疲劳、抗应激、保肝、抗病毒、提高机体免疫力、抗氧化、补血和保护心肌细胞等活性。本文主要从蕨麻的化学成分和药理活性方面综述其研究进展，提出应在现代医药理论指导下，科学开发利用传统药用植物的观点，同时对蕨麻中有效化学成分、活性成分、药理作用及其代谢机制进行系统而深入的探索，并按照合理的本草疗法进行规范化的临床实验，为进一步开发利用该植物做好基础研究。
궐마시장미과위릉채속식물아융위릉채(Potentilla anserine L.)적근，주요분포우북반구적온대、한대화고한지구，재아국주요분포우청해、서장등지。궐마주요함유치류、삼첩류、황동류、분산류화향두소류화합물등다충화학성분。중의학연구표명，궐마구유건위보비、생진해갈、익기보혈등공능。생물활성연구결과현시，궐마제취물구유내결양、항피로、항응격、보간、항병독、제고궤체면역력、항양화、보혈화보호심기세포등활성。본문주요종궐마적화학성분화약리활성방면종술기연구진전，제출응재현대의약이론지도하，과학개발이용전통약용식물적관점，동시대궐마중유효화학성분、활성성분、약리작용급기대사궤제진행계통이심입적탐색，병안조합리적본초요법진행규범화적림상실험，위진일보개발이용해식물주호기출연구。
ABSTRACT:The genus Potentilla is a member of the family Rosaceae. The root of Potentilla anserine is an important medicinal plant in traditional Chinese medicines (TCMs) and known as‘jue ma’ in TCMs, which is mainly distributed in temperate, frigid and alpine zones of the northern hemisphere. In China, it is mainly distributed in Qinghai and Tibet provinces. This genus mainly contains steroids, triterpenes, flavonoids, phenolic acids and coumarin compounds. It is suggested in traditional Chinese medicine that its functions and indications are various, such as supplementing the spleen and fortifying the stomach, promoting the production of body fluid and relieving thirst, invigorating the vital energy and nourishing the blood. Bioactivity investigations suggest the root of P. anserine has diverse biological activities, such as antioxidant, anti-fatigue, enhancing immunity, cardiomyocyte protection, and hepatoprotective effects. This article reviewed the recent research progresses on the chemical constituents and biological potentials of the root of P. anserine, and proposed the thought of scientific development and application of traditional herbal medicines under the guidance of modern pharmaceutical theories. Further systematic and deep explorations should be made on the effective constituents, active constituents, pharmaceutical functions and metabolic mechanism of the root of P. anserine and standardized clinical trials should be conducted according to reasonable herbal regimens, so as to lay the foundation of basic researches for further exploitation and utilization of this plant.