中国康复理论与实践
中國康複理論與實踐
중국강복이론여실천
Chinese Journal of Rehabilitation Theory and Practice
2015年
9期
1091-1094
,共4页
PSMA6基因%单核苷酸多态性%脑梗死
PSMA6基因%單覈苷痠多態性%腦梗死
PSMA6기인%단핵감산다태성%뇌경사
PSMA6 gene%single nucleotide polymorphism%cerebral infarction
目的：探讨中国汉族人群中PSMA6基因rs17458312(-1520C/T)位点的多态性与脑梗死的相关性。方法对211例脑梗死患者(病例组)和201例健康体检者(对照组)，应用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)检测PSMA6基因rs17458312位点单核苷酸多态性，并分析其基因型及等位基因频数的分布。结果 CC、CT、TT基因型频率及C等位基因频率在两组中分布无显著性差异(P>0.05)。性别分层后，各亚组各基因型及等位基因频率分布也无显著性差异(P>0.05)。结论 PSMA6基因rs17458312位点可能与脑梗死的发病无关。
目的：探討中國漢族人群中PSMA6基因rs17458312(-1520C/T)位點的多態性與腦梗死的相關性。方法對211例腦梗死患者(病例組)和201例健康體檢者(對照組)，應用聚閤酶鏈反應-限製性片段長度多態性分析法(PCR-RFLP)檢測PSMA6基因rs17458312位點單覈苷痠多態性，併分析其基因型及等位基因頻數的分佈。結果 CC、CT、TT基因型頻率及C等位基因頻率在兩組中分佈無顯著性差異(P>0.05)。性彆分層後，各亞組各基因型及等位基因頻率分佈也無顯著性差異(P>0.05)。結論 PSMA6基因rs17458312位點可能與腦梗死的髮病無關。
목적：탐토중국한족인군중PSMA6기인rs17458312(-1520C/T)위점적다태성여뇌경사적상관성。방법대211례뇌경사환자(병례조)화201례건강체검자(대조조)，응용취합매련반응-한제성편단장도다태성분석법(PCR-RFLP)검측PSMA6기인rs17458312위점단핵감산다태성，병분석기기인형급등위기인빈수적분포。결과 CC、CT、TT기인형빈솔급C등위기인빈솔재량조중분포무현저성차이(P>0.05)。성별분층후，각아조각기인형급등위기인빈솔분포야무현저성차이(P>0.05)。결론 PSMA6기인rs17458312위점가능여뇌경사적발병무관。
Objective To evaluate the association between rs17458312 (-1520C/T) polymorphism of PSMA6 gene and cerebral infarc-tion in Chinese Han population. Methods 211 cerebral infarction patients (case group) and 201 healthy controls (control group) were select-ed in the study. The single nucleotide polymorphism of rs17458312 of PSMA6 gene was identified with the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The genotypes and allele frequencies distributed in cerebral infarction patients and healthy controls were analyzed. Results The frequencies of CC, CT, TT genotypes and the C allele all revealed no significant difference between the case group and the control group (P>0.05). After stratified by genders, the difference among all genetypes and alleles weren't significant between subgroup (P>0.05). Conclusion The rs17458312 of PSMA6 gene might not be associated with the cerebral infarction.
