CAJ | 학술논문

脊髓损伤后各病理阶段均有各种蛋白表达，代表损伤和修复的病理变化。发现并筛选出理想的生物标志物，有助于进一步评估复杂的脊髓损伤生物反应并判断预后。目前，已有部分研究就神经元特异性烯醇化酶(NSE)、星形胶质原性钙结合蛋白S-100β作为脊髓损伤的血清学标志物进行了初步探索。但是，其特异性和敏感性仍需进一步明确。未来仍需开发能预测功能结果的理想生物标志物。
척수손상후각병리계단균유각충단백표체，대표손상화수복적병리변화。발현병사선출이상적생물표지물，유조우진일보평고복잡적척수손상생물반응병판단예후。목전，이유부분연구취신경원특이성희순화매(NSE)、성형효질원성개결합단백S-100β작위척수손상적혈청학표지물진행료초보탐색。단시，기특이성화민감성잉수진일보명학。미래잉수개발능예측공능결과적이상생물표지물。
Various functional proteins are differently expressed in each pathologic stage after spinal cord injury, representing injury and the pathological change of repair. Ideal biomarker is helpful to evaluate complicated biological reactions of spinal cord injury and predict prognosis. As specific serum markers of central nerve injury, neuron-specific enolase (NSE) and astrocyte primary calcium binding protein S-100βhad been studied preliminarily, but the specificity and sensitivity need more research. Future efforts still need to develop ideal bio-markers to predict functional outcome.