CAJ | 학술논문

神经母细胞瘤(NB)是起源于神经嵴细胞的儿童常见颅外实体瘤.二唾液酸神经节苷脂(GD)类的GD2在NB中高度表达,但在正常组织中表达水平低且仅限于中枢神经系统、周围痛觉纤维以及皮肤黑色素细胞.因此GD2是NB免疫治疗的理想靶点.现就以GD2为靶点的NB免疫治疗的研究进展进行综述.
신경모세포류(NB)시기원우신경척세포적인동상견로외실체류.이타액산신경절감지(GD)류적GD2재NB중고도표체,단재정상조직중표체수평저차부한우중추신경계통、주위통각섬유이급피부흑색소세포.인차GD2시NB면역치료적이상파점.현취이GD2위파점적NB면역치료적연구진전진행종술.
Neuroblastoma(NB),the common extracranial solid tumor of childhood,is thought to derive from neural crest cells.In disialoganglioside (GD)2 is highly expressed on NB,whereas GD2 expression is weak and restricted to the central nervous system,peripheral pain fibers and skin melanocytes.Therefore,GD2 is an ideal antigen target for immunotherapy of NB.The research progress on GD2 as target for immunotherapy of NB was reviewed.