CAJ | 학술논문

儿童恶性肿瘤是指一大类儿童时期的恶性疾病,包括2大部分:血液淋巴系统疾病和实体肿瘤,多见于15岁以下的儿童.实体肿瘤是儿童恶性肿瘤的主要组成部分,与成人实体瘤有很大差别,以母细胞源性的肿瘤为主.其发病机制除与遗传、环境2大因素有关外,可能与母亲在怀孕期甚至怀孕前期对各种致癌性环境因素暴露有密切的因果联系.胎盘是母胎进行物质交换的器官,是胚胎与母体组织的结合体,部分与胎儿在生物学和基因学上同源,同时为胎儿在宫内正常发育提供全方位保障.现对儿童恶性肿瘤病因学及其与胎盘病变的关系进行综述,以期对儿童肿瘤的病因学研究和早期诊断有所帮助.
인동악성종류시지일대류인동시기적악성질병,포괄2대부분:혈액림파계통질병화실체종류,다견우15세이하적인동.실체종류시인동악성종류적주요조성부분,여성인실체류유흔대차별,이모세포원성적종류위주.기발병궤제제여유전、배경2대인소유관외,가능여모친재부잉기심지부잉전기대각충치암성배경인소폭로유밀절적인과련계.태반시모태진행물질교환적기관,시배태여모체조직적결합체,부분여태인재생물학화기인학상동원,동시위태인재궁내정상발육제공전방위보장.현대인동악성종류병인학급기여태반병변적관계진행종술,이기대인동종류적병인학연구화조기진단유소방조.
Childhood cancers are malignancies occured during childhood,which consist of blood-lymphatic system disorders and solid tumor,usually under the age of 15 years old.Among cancers of childhood,solid tumors account for the mainly proportion and most neoplasms are embryonic origin,which are distinctly different from the adult solid tumors.The pathogenesis of children with an oncologic disease,except from the 2 major elements heredity and environment,some experts consider that there are intense correlations between various carcinogenic environment exposure during pregnancy even progestation and childhood cancers.The placenta is a combination of embryo and the maternal tissues,while is a material exchanged organ between 2 parts.One part has a same origin with fetus biological and genetics,and the other provides comprehensive guarantee for fetus normal development in utero.The research of the placental disease of childhood cancers may have a breakthrough in the study of the etiology of pediatric oncology.