国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
Journal of International Oncology
2015年
9期
679-681
,共3页
周雅博%蒋晔%庞炳昕%吴倩倩%卢珈%胡洁%刘伟
週雅博%蔣曄%龐炳昕%吳倩倩%盧珈%鬍潔%劉偉
주아박%장엽%방병흔%오천천%로가%호길%류위
基因%肿瘤%CMTM家族
基因%腫瘤%CMTM傢族
기인%종류%CMTM가족
Genes%Neoplasms%CMTM family
CMTM家族基因在多种肿瘤中表达沉默或下调,其表达异常与肿瘤的发生发展和转移联系密切,是潜在的抑癌基因.表观遗传学是该家族基因表达异常的重要机制.这一研究发现为肿瘤的临床治疗提供了新的思路.
CMTM傢族基因在多種腫瘤中錶達沉默或下調,其錶達異常與腫瘤的髮生髮展和轉移聯繫密切,是潛在的抑癌基因.錶觀遺傳學是該傢族基因錶達異常的重要機製.這一研究髮現為腫瘤的臨床治療提供瞭新的思路.
CMTM가족기인재다충종류중표체침묵혹하조,기표체이상여종류적발생발전화전이련계밀절,시잠재적억암기인.표관유전학시해가족기인표체이상적중요궤제.저일연구발현위종류적림상치료제공료신적사로.
CMTM family is silenced and down-regulated in several kinds of tumors.Its aberrant expression has a strong association with the development,progression and metastasis of tumors.Thus,CMTM family is potential tumor suppressor genes.Epigenetics mechanism is the essential mechanism of the aberrant expression in this gene family.The discovery of this research gives a new direction to the clinical treatment of tumor.
