国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
Journal of International Oncology
2015年
9期
649-652
,共4页
瘦素%雌激素类%雌激素受体%肺腺癌,细支气管肺泡
瘦素%雌激素類%雌激素受體%肺腺癌,細支氣管肺泡
수소%자격소류%자격소수체%폐선암,세지기관폐포
Leptin%Estrogens%Receptors,estrogen%Adenocarcinoma,bronchiolo-alveolar
目的 探讨瘦素、雌激素及雌激素受体(ER)在肺腺癌中的表达及意义.方法 对58例肺腺癌(肺腺癌组)、63例肺鳞状细胞癌(肺鳞状细胞癌组)及50例正常肺组织(正常对照组)标本,用免疫组织化学法检测瘦素和ER的表达,同时检测患者静脉血中雌激素水平,比较瘦素、雌激素及ER在肺腺癌与肺鳞状细胞癌、正常组织中表达的差异,分析其与肺腺癌临床病理学特征间的相关性.结果 瘦素、雌激素及ER在肺腺癌组中阳性率分别为65.5％、36.2％、58.6％,在肺鳞状细胞癌组中的阳性率分别为33.3％、15.9％、30.2％,两组比较差异有统计学意义(x2=4.324,P＜0.050;x2 =5.372,P＜0.050;x2 =5.718,P＜0.050);三者在正常对照组中的阳性率分别为24.0％、4.0％和0,与肺腺癌组比较差异有统计学意义(x2=7.126,P＜0.010;x2=9.683,P＜0.005;x2=22.308,P＜0.005).瘦素、雌激素及ER与肺腺癌肿瘤临床分期(x2 =0.001,P=0.950;x2 =0.061,P=0.900;x2 =0.178,P=0.750)、原发灶大小(x2=0.023,P=0.900;x2 =0.001,P=0.950;x2=0.001,P=0.950)无关.结论 瘦素、雌激素及ER在肺腺癌组织中均呈现高表达,与肺腺癌的发生、发展和临床类型可能存在一定相关性,与肺腺癌临床病理学特征间无明显相关性.
目的 探討瘦素、雌激素及雌激素受體(ER)在肺腺癌中的錶達及意義.方法 對58例肺腺癌(肺腺癌組)、63例肺鱗狀細胞癌(肺鱗狀細胞癌組)及50例正常肺組織(正常對照組)標本,用免疫組織化學法檢測瘦素和ER的錶達,同時檢測患者靜脈血中雌激素水平,比較瘦素、雌激素及ER在肺腺癌與肺鱗狀細胞癌、正常組織中錶達的差異,分析其與肺腺癌臨床病理學特徵間的相關性.結果 瘦素、雌激素及ER在肺腺癌組中暘性率分彆為65.5％、36.2％、58.6％,在肺鱗狀細胞癌組中的暘性率分彆為33.3％、15.9％、30.2％,兩組比較差異有統計學意義(x2=4.324,P＜0.050;x2 =5.372,P＜0.050;x2 =5.718,P＜0.050);三者在正常對照組中的暘性率分彆為24.0％、4.0％和0,與肺腺癌組比較差異有統計學意義(x2=7.126,P＜0.010;x2=9.683,P＜0.005;x2=22.308,P＜0.005).瘦素、雌激素及ER與肺腺癌腫瘤臨床分期(x2 =0.001,P=0.950;x2 =0.061,P=0.900;x2 =0.178,P=0.750)、原髮竈大小(x2=0.023,P=0.900;x2 =0.001,P=0.950;x2=0.001,P=0.950)無關.結論 瘦素、雌激素及ER在肺腺癌組織中均呈現高錶達,與肺腺癌的髮生、髮展和臨床類型可能存在一定相關性,與肺腺癌臨床病理學特徵間無明顯相關性.
목적 탐토수소、자격소급자격소수체(ER)재폐선암중적표체급의의.방법 대58례폐선암(폐선암조)、63례폐린상세포암(폐린상세포암조)급50례정상폐조직(정상대조조)표본,용면역조직화학법검측수소화ER적표체,동시검측환자정맥혈중자격소수평,비교수소、자격소급ER재폐선암여폐린상세포암、정상조직중표체적차이,분석기여폐선암림상병이학특정간적상관성.결과 수소、자격소급ER재폐선암조중양성솔분별위65.5％、36.2％、58.6％,재폐린상세포암조중적양성솔분별위33.3％、15.9％、30.2％,량조비교차이유통계학의의(x2=4.324,P＜0.050;x2 =5.372,P＜0.050;x2 =5.718,P＜0.050);삼자재정상대조조중적양성솔분별위24.0％、4.0％화0,여폐선암조비교차이유통계학의의(x2=7.126,P＜0.010;x2=9.683,P＜0.005;x2=22.308,P＜0.005).수소、자격소급ER여폐선암종류림상분기(x2 =0.001,P=0.950;x2 =0.061,P=0.900;x2 =0.178,P=0.750)、원발조대소(x2=0.023,P=0.900;x2 =0.001,P=0.950;x2=0.001,P=0.950)무관.결론 수소、자격소급ER재폐선암조직중균정현고표체,여폐선암적발생、발전화림상류형가능존재일정상관성,여폐선암림상병이학특정간무명현상관성.
Objective To study the expressions and significances of leptin,estrogen and estrogen receptor (ER) in pulmonary squamous carcinoma and adenocarcinoma.Methods The expressions of leptin and estrogen receptor were detected in 58 cases of lung adenocarcinoma and 63 cases of pulmonary squamous cell carcinoma and 50 cases of normal lung tissue samples by immunohistochemical menthod,the levels of estrogen were also detected in patients with venous blood at the same time.Comparison of differential expression of leptin,estrogen and estrogen receptor in lung adenocarcinoma and lung squamous cell carcinoma,normal tissues,and explore their relationships with lung adenocarcinoma.Results Leptin,estrogen and estrogen receptor positive rates in lung adenocarcinoma group were 65.5％,36.2％ and 58.6％ respectively,and 33.3％,15.9％,30.2％ in lung squamous cell carcinoma group.There were a statistical difference between the two groups (x2 =4.324,P＜0.050;x2 =5.372,P ＜0.050;x2 =5.718,P ＜0.050).In the normal control group the positive rates were 24.0％,4.0％ and 0 respectively,and there was a statistical difference compared with lung adenocarcinoma group (x2 =7.126,P ＜0.010;x2 =9.683,P＜0.005;x2 =22.308,P ＜0.005).In lung adenocarcinoma group,leptin,estrogen and estrogen receptor positive rate have no relationships with tumor stage (x2 =0.001,P=0.950;x2 =0.061,P =0.900;x2 =0.178,P=0.750) and primary tumor size (x2=0.023,P=0.900;x2 =0.001,P=0.950;x2 =0.001,P=0.950).Conclusion Leptin,estrogen and ER were expressed highly in adenocarcinoma of lung tumor.The expressions of leptin,estrogen and ER may associated with the carcinogenesis,development and clinical type of adenocarcinoma of lung.
