国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
Journal of International Oncology
2015年
9期
671-674
,共4页
RNA%后成说,遗传%肿瘤
RNA%後成說,遺傳%腫瘤
RNA%후성설,유전%종류
RNA%Epigenesis,genetic%Neoplasms
长非编码RNA (lncRNA)的异常表达与多种肿瘤相关.最新研究发现,lncRNA一方面可以通过多种途径调控其他表观遗传方式,包括DNA甲基化、组蛋白修饰、miRNA、染色质重构;另一方面,其他表观遗传形式也能够调控lncRNA的表达,两者的相互调控对恶性肿瘤的发生和发展起着重要作用.对其中机制的深入研究有助于更加清晰地阐明肿瘤的发生机制,并为以lncRNA为靶点的肿瘤治疗提供理论基础.
長非編碼RNA (lncRNA)的異常錶達與多種腫瘤相關.最新研究髮現,lncRNA一方麵可以通過多種途徑調控其他錶觀遺傳方式,包括DNA甲基化、組蛋白脩飾、miRNA、染色質重構;另一方麵,其他錶觀遺傳形式也能夠調控lncRNA的錶達,兩者的相互調控對噁性腫瘤的髮生和髮展起著重要作用.對其中機製的深入研究有助于更加清晰地闡明腫瘤的髮生機製,併為以lncRNA為靶點的腫瘤治療提供理論基礎.
장비편마RNA (lncRNA)적이상표체여다충종류상관.최신연구발현,lncRNA일방면가이통과다충도경조공기타표관유전방식,포괄DNA갑기화、조단백수식、miRNA、염색질중구;령일방면,기타표관유전형식야능구조공lncRNA적표체,량자적상호조공대악성종류적발생화발전기착중요작용.대기중궤제적심입연구유조우경가청석지천명종류적발생궤제,병위이lncRNA위파점적종류치료제공이론기출.
Abnormal expressions of long non-coding RNAs (LncRNAs) are associated with a variety of tumors.Recent studies show that lncRNA can regulate other epigenetic processes such as DNA methylation,histone modifications,chromatin remodeling and miRNA through various ways;on the other side,other epigenetic processes can influence the expression of lncRNA.The mutual regulation of them paly important roles in the occurrence and development of malignant tumors.The better understanding of the crosstalk between lncRNA and epigenetic modulation will contribute to clearly clarify the mechanism of tumor,which provides a theoretical basis for the anti-cancer therapies targeting lncRNAs.
