CAJ | 학술논문

特发性肺纤维化是一种病因不明的、进展性的疾病,有较高的病死率,中位生存期仅3年,缺少有效治疗手段.研究表明病毒感染可导致特发性肺纤维化的发生、发展及急性加重,抗病毒治疗有可能缓解症状,延缓病情进展.本文主要阐述病毒感染作为特发性肺纤维化发病原因的依据,并通过肺纤维化动物模型来探讨其可能机制.
특발성폐섬유화시일충병인불명적、진전성적질병,유교고적병사솔,중위생존기부3년,결소유효치료수단.연구표명병독감염가도치특발성폐섬유화적발생、발전급급성가중,항병독치료유가능완해증상,연완병정진전.본문주요천술병독감염작위특발성폐섬유화발병원인적의거,병통과폐섬유화동물모형래탐토기가능궤제.
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown origin and progression.The mortality of IPF is higher,median survival time is three years.This is due to lack of effective therapies to halt disease progression.Accumulating evidences suggest that viral infection may play a key role in the initiation,progression and acute exacerbation of IPF.It is possible that therapeutic strategies,utilising available antiviral,may be effective in halting the progression of IPF.This article summarizes the evidences for the notion that virus may contribute to IPF.In addition,we review mechanistic studies in animal models that highlight the fibrotic potential of viral infection,and explore the different mechanisms.