CAJ | 학술논문

目的：探讨晚期卵巢癌患者新辅助化疗后组织生物标记物的表达变化及其意义。方法61例晚期卵巢癌患者随机分成研究组和对照组，采用免疫组化法检测肿瘤标记物p53、ER、PR、MIB1、Bcl2、E-cadherin和Her-2/neu表达，并进行对比研究，分析其与预后的关系。结果 MIB1两组比较有统计学差异。且MIB1低表达预示患者预后较好。ER阳性表达与预后差相关。其它标记物表达与预后两组之间无明显差异。结论卵巢上皮癌组织有多种肿瘤生物标记物表达，而MIB1和ER的检测可以指导治疗和判断预后。
목적：탐토만기란소암환자신보조화료후조직생물표기물적표체변화급기의의。방법61례만기란소암환자수궤분성연구조화대조조，채용면역조화법검측종류표기물p53、ER、PR、MIB1、Bcl2、E-cadherin화Her-2/neu표체，병진행대비연구，분석기여예후적관계。결과 MIB1량조비교유통계학차이。차MIB1저표체예시환자예후교호。ER양성표체여예후차상관。기타표기물표체여예후량조지간무명현차이。결론란소상피암조직유다충종류생물표기물표체，이MIB1화ER적검측가이지도치료화판단예후。
Objective To evaluate the expression of tissue biomarkers and clinical significance.Methods 61 cases of advanced ovarian cancer were radomly divided into study group and control group,tested the expression of p53、 ER、PR 、MIB1 、Bcl2、Her-2/neu,E-cadherin,and analyzed the relationship between the expression and prognosis.Results There were significant differences in MIB1 in the two groups. And low expression of MIB1 indicated that the prognosis of patients was wel.Expression of ER was associated with poor prognosis. No significant differences in the expression of other markers and prognosis between the two groups.ConclusionER and MIB1 are important for the treatment and prognosis of ovarian epithelial carcinoma.