CAJ | 학술논문

目的：研制微粉化双黄朴水凝胶贴剂，并观察其体外释药性能及透皮吸收特点。方法以水溶性高分子材料为辅料制备微粉化双黄朴水凝胶贴剂；高效液相色谱法测定小檗碱的经皮吸收量，按?中华人民共和国药典?2010年版要求进行体外释放度测定，采用改良的Franz扩散池法研究水凝胶贴剂的经皮吸收特点。结果水凝胶贴剂含药量稳定，体外释药符合 Higuchi 分布方程，水凝胶贴剂中的小檗碱在12 h 内透皮为零级过程，释放速率是7.934μg??( cm2)－1??h1/2，透皮速率为0.571μg??( cm2)－1??h－1。结论微粉化双黄朴水凝胶贴剂为一种新型控释型经皮给药制剂。
목적：연제미분화쌍황박수응효첩제，병관찰기체외석약성능급투피흡수특점。방법이수용성고분자재료위보료제비미분화쌍황박수응효첩제；고효액상색보법측정소벽감적경피흡수량，안?중화인민공화국약전?2010년판요구진행체외석방도측정，채용개량적Franz확산지법연구수응효첩제적경피흡수특점。결과수응효첩제함약량은정，체외석약부합 Higuchi 분포방정，수응효첩제중적소벽감재12 h 내투피위령급과정，석방속솔시7.934μg??( cm2)－1??h1/2，투피속솔위0.571μg??( cm2)－1??h－1。결론미분화쌍황박수응효첩제위일충신형공석형경피급약제제。
Objective To study preparation of micronized Shuanghuangpo hydrogel patch and its characteristics of transdermal penetration in vitro. Methods Micronized Shuanghuangpo hydrogel patch was prepared with some macromolecular water-soluble materials as gel base.The content of berberine was determined by HPLC method.Its transdermal penetration in vitro was determined according to the method of Chinese Pharmacopoeia 2010 edition. The rat skin penetration test in vitro was performed by modified Franz diffusion cell method. Results The hydrogel patch had constant content of berberine. Its release property in vitro conformed to Higuchi equation. The penetration of berberine in the hydrogel patch through the rat skin followed zero-order dynamics in 12 h.Its release rate was 7.934μg??(cm2)-1??h1/2 and percutaneous rate was 0.571μg??(cm2)-1??h-1. Conclusion The micronized Shuanghuangpo hydrogel patch is a new transdermal agent with sustained release property.