新医学
新醫學
신의학
New Medicine
2015年
9期
593-596
,共4页
刘擘%冯敏%付莎%徐安平
劉擘%馮敏%付莎%徐安平
류벽%풍민%부사%서안평
系统性红斑狼疮%神经精神性狼疮%狼疮性肾炎%痫性发作%危险因素
繫統性紅斑狼瘡%神經精神性狼瘡%狼瘡性腎炎%癇性髮作%危險因素
계통성홍반랑창%신경정신성랑창%랑창성신염%간성발작%위험인소
Systemic lupus erythematosus%Neuropsychiatric systemic lupus erythematosus%Nephritis lupus%Epileptic seizure%Risk factor
目的：分析合并狼疮性肾炎（LN）的神经精神性狼疮（NPSLE）患者痫性发作的危险因素。方法收集115例 NPSLE 合并 LN 住院患者的临床资料，比较痫性发作者和非痫性发作者的临床特点，包括一般情况、器官受累情况、实验室检查及治疗，并采用单因素及多因素 Logistic 回归进行危险因素分析。结果115例 NPSLE 合并 LN 住院患者中，纳入痫性发作组53例，非痫性发作组62例。2组患者的 NPSLE 发病年龄、SLE 病程、血清白蛋白、血清总胆固醇、血清甘油三酯、血清LDL-C 水平比较差异均有统计学意义（P 均＜0.05）。多因素 Logistic 回归显示，NPSLE 合并 LN 患者痫性发作的独立危险因素包括未成年发病（OR ＝2.976，95％CI：1.044～8.475，P ＝0.041）、低白蛋白血症（OR ＝0.888，95％ CI：0.824～0.958，P ＝0.002）、LDL-C 偏高（OR ＝1.393，95％ CI：1.050～1.847，P ＝0.021）。结论未成年发病是合并 LN 的 NPSLE 患者痫性发作的独立危险因素，血清白蛋白水平越低、血 LDL-C 水平越高，痫性发作的危险性越高。
目的：分析閤併狼瘡性腎炎（LN）的神經精神性狼瘡（NPSLE）患者癇性髮作的危險因素。方法收集115例 NPSLE 閤併 LN 住院患者的臨床資料，比較癇性髮作者和非癇性髮作者的臨床特點，包括一般情況、器官受纍情況、實驗室檢查及治療，併採用單因素及多因素 Logistic 迴歸進行危險因素分析。結果115例 NPSLE 閤併 LN 住院患者中，納入癇性髮作組53例，非癇性髮作組62例。2組患者的 NPSLE 髮病年齡、SLE 病程、血清白蛋白、血清總膽固醇、血清甘油三酯、血清LDL-C 水平比較差異均有統計學意義（P 均＜0.05）。多因素 Logistic 迴歸顯示，NPSLE 閤併 LN 患者癇性髮作的獨立危險因素包括未成年髮病（OR ＝2.976，95％CI：1.044～8.475，P ＝0.041）、低白蛋白血癥（OR ＝0.888，95％ CI：0.824～0.958，P ＝0.002）、LDL-C 偏高（OR ＝1.393，95％ CI：1.050～1.847，P ＝0.021）。結論未成年髮病是閤併 LN 的 NPSLE 患者癇性髮作的獨立危險因素，血清白蛋白水平越低、血 LDL-C 水平越高，癇性髮作的危險性越高。
목적：분석합병랑창성신염（LN）적신경정신성랑창（NPSLE）환자간성발작적위험인소。방법수집115례 NPSLE 합병 LN 주원환자적림상자료，비교간성발작자화비간성발작자적림상특점，포괄일반정황、기관수루정황、실험실검사급치료，병채용단인소급다인소 Logistic 회귀진행위험인소분석。결과115례 NPSLE 합병 LN 주원환자중，납입간성발작조53례，비간성발작조62례。2조환자적 NPSLE 발병년령、SLE 병정、혈청백단백、혈청총담고순、혈청감유삼지、혈청LDL-C 수평비교차이균유통계학의의（P 균＜0.05）。다인소 Logistic 회귀현시，NPSLE 합병 LN 환자간성발작적독립위험인소포괄미성년발병（OR ＝2.976，95％CI：1.044～8.475，P ＝0.041）、저백단백혈증（OR ＝0.888，95％ CI：0.824～0.958，P ＝0.002）、LDL-C 편고（OR ＝1.393，95％ CI：1.050～1.847，P ＝0.021）。결론미성년발병시합병 LN 적 NPSLE 환자간성발작적독립위험인소，혈청백단백수평월저、혈 LDL-C 수평월고，간성발작적위험성월고。
Objective To determine the risk factors of epileptic seizure in patients with neuropsychi-atric systemic lupus erythematosus (NPSLE)complicated with nephritis lupus (LN).Methods Clinical data of 115 hospitalized patients diagnosed with NPSLE complicated with LN were collected.Clinical characteristics including general conditions,involved organs,laboratory examination and treatment were statistically compared between the epileptic seizure and non-epileptic seizure patients.Univariate and multivariate logistic regression analyses were performed to analyze the risk factors.Results Among 115 NPSLE patients complicated with LN,53 were allocated into the epileptic seizure group and 62 into the non-epileptic seizure group.The age of onset of NPSLE,duration of systemic lupus erythematosus (SLE),serum albumin,serum total cholesterol,se-rum triglyceride,serum low-density lipoprotein cholesterol (LDL-C)significantly differed between two groups (all P <0.05).Multivariate logistic regression analysis revealed that juvenile onset (OR =2.976,95%CI:1.044 ~8.475,P =0.041),hypoalbuminemia (OR =0.888,95%CI:0.824 ~0.958,P =0.002),and high level of LDL-C (OR =1.393,95%CI:1.050 ~1.847,P =0.021)were the risk factors of epileptic seizures in NPSLE patients complicated with LN.Conclusions Juvenile onset is an independent risk factor of epileptic seizure in NPSLE patients complicated with LN.Lower levels of serum albumin and higher levels of serum LDL-C are associated with increased risk of epileptic seizure.
