中国医学创新
中國醫學創新
중국의학창신
Medical Innovation of China
2015年
27期
32-34
,共3页
心型脂肪酸结合蛋白%慢性心功能不全%危险程度%预后
心型脂肪痠結閤蛋白%慢性心功能不全%危險程度%預後
심형지방산결합단백%만성심공능불전%위험정도%예후
Heart-type fatty acid- binding protein%Chronic congestive heart failure%Risk stratification%Prognosis
目的：研究心型脂肪酸结合蛋白（H-FABP）对慢性充血性心力衰竭（CHF）危险程度及预后的影响。方法：CHF组纳入80例CHF患者，按照纽约心功能分级标准分为心功能Ⅱ、Ⅲ、Ⅳ三个亚组，对照组为65例健康体检者。两组均检测血浆H-FABP、NT-proBNP、cTnI、CKMB浓度，并做统计学分析。随访时间至少为1年，统计心脏不良事件的发生率。结果：CHF各组与对照组比较H-FABP、NT-proBNP、cTnI差异均有统计学意义（P<0.05）；亚组分析随着心功能级别的升高，H-FABP、NT-proBNP水平逐渐升高，差异均有统计学意义（P<0.05）；而cTnI、CKMB亚组间比较差异无统计学意义（P>0.05）。H-FABP阳性组、NT-proBNP阳性组死亡例数比例相对较高，但与其余两组比较差异无统计学意义（P>0.05）；H-FABP阳性组再入院率及顽固性心衰发生率均比cTnI阳性组、CKMB阳性组高，差异均有统计学意义（P<0.05）。多因素logistic分析发现NT-proBNP、H-FABP与全因死亡率相关（P<0.05）。结论：H-FABP能够对CHF危险程度进行分级，有利于评估远期预后。
目的：研究心型脂肪痠結閤蛋白（H-FABP）對慢性充血性心力衰竭（CHF）危險程度及預後的影響。方法：CHF組納入80例CHF患者，按照紐約心功能分級標準分為心功能Ⅱ、Ⅲ、Ⅳ三箇亞組，對照組為65例健康體檢者。兩組均檢測血漿H-FABP、NT-proBNP、cTnI、CKMB濃度，併做統計學分析。隨訪時間至少為1年，統計心髒不良事件的髮生率。結果：CHF各組與對照組比較H-FABP、NT-proBNP、cTnI差異均有統計學意義（P<0.05）；亞組分析隨著心功能級彆的升高，H-FABP、NT-proBNP水平逐漸升高，差異均有統計學意義（P<0.05）；而cTnI、CKMB亞組間比較差異無統計學意義（P>0.05）。H-FABP暘性組、NT-proBNP暘性組死亡例數比例相對較高，但與其餘兩組比較差異無統計學意義（P>0.05）；H-FABP暘性組再入院率及頑固性心衰髮生率均比cTnI暘性組、CKMB暘性組高，差異均有統計學意義（P<0.05）。多因素logistic分析髮現NT-proBNP、H-FABP與全因死亡率相關（P<0.05）。結論：H-FABP能夠對CHF危險程度進行分級，有利于評估遠期預後。
목적：연구심형지방산결합단백（H-FABP）대만성충혈성심력쇠갈（CHF）위험정도급예후적영향。방법：CHF조납입80례CHF환자，안조뉴약심공능분급표준분위심공능Ⅱ、Ⅲ、Ⅳ삼개아조，대조조위65례건강체검자。량조균검측혈장H-FABP、NT-proBNP、cTnI、CKMB농도，병주통계학분석。수방시간지소위1년，통계심장불량사건적발생솔。결과：CHF각조여대조조비교H-FABP、NT-proBNP、cTnI차이균유통계학의의（P<0.05）；아조분석수착심공능급별적승고，H-FABP、NT-proBNP수평축점승고，차이균유통계학의의（P<0.05）；이cTnI、CKMB아조간비교차이무통계학의의（P>0.05）。H-FABP양성조、NT-proBNP양성조사망례수비례상대교고，단여기여량조비교차이무통계학의의（P>0.05）；H-FABP양성조재입원솔급완고성심쇠발생솔균비cTnI양성조、CKMB양성조고，차이균유통계학의의（P<0.05）。다인소logistic분석발현NT-proBNP、H-FABP여전인사망솔상관（P<0.05）。결론：H-FABP능구대CHF위험정도진행분급，유리우평고원기예후。
Objective:To investigate the relationship of heart-type fatty acid- binding protein (H-FABP) and chronic congestive heart failure (CHF).Method:The CHF group included 80 patients with CHF,they were divided into NYHA Ⅱ, Ⅲ and Ⅳ three subgroups. The control group were 65 healthy person.Serum concentrations of H-FABP, NT-proBNP and cTnI of two groups were measured. Followed-up at least a year, the major adverse cardiac events were recorded.Result:Serum concentrations of H-FABP,NT-proBNP and cTnI of CHF group were higher than control group, the differences were statistically significant(P<0.05).The level of H-FABP,NT-pro BNP increased gradually of CHF subgroups with the different classification, the differences were statistically significant(P<0.05),but there was no significant difference between cTnI subgroup and CKMB subgroup(P>0.05).The deaths proportion of H-FABP positive group and NT-proBNP positive group were higher than the rest two groups,but had no statistical difference(P>0.05). The incidence of readmission and refractory heart failure in H-FABP positive group were higher than cTnI group and CKMB group,the differences were statistically significant (P<0.05).Multiariable logistic regression analysis found that NT-proBNP and H-FABP associated with all-cause mortality(P<0.05).Conclusion:The detection of H-FABP can be help for assessment risk stratification and prognosis for patients with CHF.
