CAJ | 학술논문

目的：探讨轻度认知功能障碍（ MCI）患者尿液中潜在的生物标志物。方法通过超高效液相色谱-质谱联用和代谢组学的方法，考查MCI患者和正常老年人尿液中代谢产物的扰动。对于超高效液相色谱-质谱联用所产生的色谱图，进行主成分分析显示出疾病组和正常组之间的代谢物的变化。结果 MCI患者的鞘氨醇类相对于正常组变化明显，5个潜在的与MCI相关的生物标志物被发现。结论 MCI患者的代谢物谱发生了明显改变，这可以为MCI的诊断提供依据。
목적：탐토경도인지공능장애（ MCI）환자뇨액중잠재적생물표지물。방법통과초고효액상색보-질보련용화대사조학적방법，고사MCI환자화정상노년인뇨액중대사산물적우동。대우초고효액상색보-질보련용소산생적색보도，진행주성분분석현시출질병조화정상조지간적대사물적변화。결과 MCI환자적초안순류상대우정상조변화명현，5개잠재적여MCI상관적생물표지물피발현。결론 MCI환자적대사물보발생료명현개변，저가이위MCI적진단제공의거。
Objective To explore potential biomarkers in urine for mild cognitive impairment(MCI).Methods Urine metabolic perturbations between MCI and healthy old person were investigated by using ultra performance liquid chromatography/mass spectrometry (UPLC/MS)and metabonomics approach.The principal component analysis(PCA)of UPLC/MS spectra showed that metabolic changes be-tween two groups.Results The PCA of UPLC/MS spectra showed that metabolic changes observed between MCI and control were clear.Five potential biomarkers in correlation with the extent of MCI were found.Conclusions The perturbation of phospholipids metabolism of MCI diseases may be important for clinical diagnosis and treatment.