中华肾病研究电子杂志
中華腎病研究電子雜誌
중화신병연구전자잡지
Chinese Journal of Kidney disease investigation (Electronic Version)
2015年
4期
212-214
,共3页
细胞程序性死亡%糖尿病肾病%发病机制
細胞程序性死亡%糖尿病腎病%髮病機製
세포정서성사망%당뇨병신병%발병궤제
Programmed cell death%Diabetic nephropathy%Pathogenesis
糖尿病肾病是糖尿病常见微血管病变,其发病机制并不完全清楚,研究发现细胞程序性死亡与糖尿病肾病发病机制关系密切,包括内质网应激、线粒体功能异常、糖基化产物毒性、糖原合酶激酶 GSK3等机制均认为与糖尿病肾病细胞程序性死亡相关,表现为自噬功能障碍,肾脏固有细胞凋亡增加以及出现某些潜在的新型细胞程序性死亡过程。本综述结合目前国内外研究现状,对这一领域做一总结。
糖尿病腎病是糖尿病常見微血管病變,其髮病機製併不完全清楚,研究髮現細胞程序性死亡與糖尿病腎病髮病機製關繫密切,包括內質網應激、線粒體功能異常、糖基化產物毒性、糖原閤酶激酶 GSK3等機製均認為與糖尿病腎病細胞程序性死亡相關,錶現為自噬功能障礙,腎髒固有細胞凋亡增加以及齣現某些潛在的新型細胞程序性死亡過程。本綜述結閤目前國內外研究現狀,對這一領域做一總結。
당뇨병신병시당뇨병상견미혈관병변,기발병궤제병불완전청초,연구발현세포정서성사망여당뇨병신병발병궤제관계밀절,포괄내질망응격、선립체공능이상、당기화산물독성、당원합매격매 GSK3등궤제균인위여당뇨병신병세포정서성사망상관,표현위자서공능장애,신장고유세포조망증가이급출현모사잠재적신형세포정서성사망과정。본종술결합목전국내외연구현상,대저일영역주일총결。
Diabetic nephropathy (DN)is a common microvascular complication of diabetes,and its pathogenesis is not entirely clear yet.It has been reported that programmed cell death (PCD)is closely associated with the pathogenesis of DN through pathways including endoplasmic reticulum stress, mitochondrial dysfunction,glycosylation products toxicity,and glycogen synthase kinase GSK3,which can lead to autophagy dysfunction,apoptosis increase of renal inherent cells,and PCD of some potential new types of cells.This review summarized the current domestic and international research data of this field.