中华肾病研究电子杂志
中華腎病研究電子雜誌
중화신병연구전자잡지
Chinese Journal of Kidney disease investigation (Electronic Version)
2015年
4期
208-211
,共4页
肿瘤坏死因子相关的凋亡诱导配体%受体%肾脏疾病
腫瘤壞死因子相關的凋亡誘導配體%受體%腎髒疾病
종류배사인자상관적조망유도배체%수체%신장질병
TNF-related apoptosis-inducing ligand (TRAIL)%Receptor%Kidney diseases
肿瘤坏死因子（TNF）相关的凋亡诱导配体（TRAIL）是肿瘤坏死因子超家族中重要的促凋亡细胞因子。TRAIL 通过与死亡受体（DR）结合发挥促凋亡效应，同时该效应受诱骗受体（DcR）的调节，进而发挥抗凋亡、促增殖等作用。TRAIL 同各类受体结合所致的病理损伤效应参与糖尿病肾病（DN）、狼疮肾炎（LN）、移植性肾病等肾脏疾病进展，并与其预后密切相关。本文将简要介绍 TRAIL、TRAIL 受体的结构与功能及其在肾脏疾病中的作用。
腫瘤壞死因子（TNF）相關的凋亡誘導配體（TRAIL）是腫瘤壞死因子超傢族中重要的促凋亡細胞因子。TRAIL 通過與死亡受體（DR）結閤髮揮促凋亡效應，同時該效應受誘騙受體（DcR）的調節，進而髮揮抗凋亡、促增殖等作用。TRAIL 同各類受體結閤所緻的病理損傷效應參與糖尿病腎病（DN）、狼瘡腎炎（LN）、移植性腎病等腎髒疾病進展，併與其預後密切相關。本文將簡要介紹 TRAIL、TRAIL 受體的結構與功能及其在腎髒疾病中的作用。
종류배사인자（TNF）상관적조망유도배체（TRAIL）시종류배사인자초가족중중요적촉조망세포인자。TRAIL 통과여사망수체（DR）결합발휘촉조망효응，동시해효응수유편수체（DcR）적조절，진이발휘항조망、촉증식등작용。TRAIL 동각류수체결합소치적병리손상효응삼여당뇨병신병（DN）、랑창신염（LN）、이식성신병등신장질병진전，병여기예후밀절상관。본문장간요개소 TRAIL、TRAIL 수체적결구여공능급기재신장질병중적작용。
TNF-related apoptosis-inducing ligand (TRAIL)is an important pro-apoptotic cytokine belonging to the TNF superfamily.TRAIL has its pro-apoptosis effect by binding to death receptors (DR), which is regulated by decoy receptors (DcR)leading to anti-apoptosis and promoting proliferation functions, etc.TRAIL combines with different receptors triggering various pathological actions so as to participate in the progression of kidney diseases including diabetic nephropathy,and is closely related to the prognosis of the kidney diseases.This review will describe the structures and functions of TRAIL as well as its receptors,and will introduce their roles in kidney diseases.
