中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
Chinese Journal of the Frontiers of Medical Science (Electronic Version)
2015年
8期
92-95
,共4页
帕尔哈提?塔衣尔%再努热木?艾则孜%梁杰
帕爾哈提?塔衣爾%再努熱木?艾則孜%樑傑
파이합제?탑의이%재노열목?애칙자%량걸
慢性心力衰竭%B型脑钠肽%血尿酸%心功能
慢性心力衰竭%B型腦鈉肽%血尿痠%心功能
만성심력쇠갈%B형뇌납태%혈뇨산%심공능
Chronic heart failure%Natriuretic peptide%Serum uric acid%Heart function
目的：探讨慢性心力衰竭患者血浆B型脑钠肽（BNP）、血尿酸水平与心功能的相关性。方法选择90例慢性心力衰竭患者（慢性心力衰竭组）和50例同期健康体检者（对照组）为研究对象。比较两组研究对象血浆BNP、血尿酸、左心室舒张末期内径（LVDd）、左心房舒张末期内径（LADd）、左心室射血分数（LVEF），并比较不同心功能分级的慢性心力衰竭患者及左心室超声参数正常组与异常组患者血浆BNP和血尿酸水平，分析其与左心室功能的相关性。结果慢性心力衰竭组患者血浆BNP和血尿酸水平、LADd、LVDd均显著高于对照组，LVEF显著低于对照组（P＜0.05）。不同心功能分级患者血浆BNP、血尿酸水平比较差异具有显著性（P＜0.05）。左心室超声参数异常组患者血浆BNP、血尿酸水平明显高于正常组（P＜0.05）。慢性心力衰竭患者血浆BNP水平与心功能分级、血尿酸水平、LADd和LVDd呈正相关，与LVEF呈负相关；血尿酸水平与心功能分级、LADd和LVDd呈正相关，与LVEF呈负相关。结论血浆BNP和血尿酸水平升高与心脏功能有一定的相关性，其升高程度越大提示心功能越差，可以作为心功能的预测指标。
目的：探討慢性心力衰竭患者血漿B型腦鈉肽（BNP）、血尿痠水平與心功能的相關性。方法選擇90例慢性心力衰竭患者（慢性心力衰竭組）和50例同期健康體檢者（對照組）為研究對象。比較兩組研究對象血漿BNP、血尿痠、左心室舒張末期內徑（LVDd）、左心房舒張末期內徑（LADd）、左心室射血分數（LVEF），併比較不同心功能分級的慢性心力衰竭患者及左心室超聲參數正常組與異常組患者血漿BNP和血尿痠水平，分析其與左心室功能的相關性。結果慢性心力衰竭組患者血漿BNP和血尿痠水平、LADd、LVDd均顯著高于對照組，LVEF顯著低于對照組（P＜0.05）。不同心功能分級患者血漿BNP、血尿痠水平比較差異具有顯著性（P＜0.05）。左心室超聲參數異常組患者血漿BNP、血尿痠水平明顯高于正常組（P＜0.05）。慢性心力衰竭患者血漿BNP水平與心功能分級、血尿痠水平、LADd和LVDd呈正相關，與LVEF呈負相關；血尿痠水平與心功能分級、LADd和LVDd呈正相關，與LVEF呈負相關。結論血漿BNP和血尿痠水平升高與心髒功能有一定的相關性，其升高程度越大提示心功能越差，可以作為心功能的預測指標。
목적：탐토만성심력쇠갈환자혈장B형뇌납태（BNP）、혈뇨산수평여심공능적상관성。방법선택90례만성심력쇠갈환자（만성심력쇠갈조）화50례동기건강체검자（대조조）위연구대상。비교량조연구대상혈장BNP、혈뇨산、좌심실서장말기내경（LVDd）、좌심방서장말기내경（LADd）、좌심실사혈분수（LVEF），병비교불동심공능분급적만성심력쇠갈환자급좌심실초성삼수정상조여이상조환자혈장BNP화혈뇨산수평，분석기여좌심실공능적상관성。결과만성심력쇠갈조환자혈장BNP화혈뇨산수평、LADd、LVDd균현저고우대조조，LVEF현저저우대조조（P＜0.05）。불동심공능분급환자혈장BNP、혈뇨산수평비교차이구유현저성（P＜0.05）。좌심실초성삼수이상조환자혈장BNP、혈뇨산수평명현고우정상조（P＜0.05）。만성심력쇠갈환자혈장BNP수평여심공능분급、혈뇨산수평、LADd화LVDd정정상관，여LVEF정부상관；혈뇨산수평여심공능분급、LADd화LVDd정정상관，여LVEF정부상관。결론혈장BNP화혈뇨산수평승고여심장공능유일정적상관성，기승고정도월대제시심공능월차，가이작위심공능적예측지표。
ObjectiveTo investigate the correlation of heart function with blood plasma B-type natriuretic peptide (BNP) and serum uric acid in patients with chronic heart failure (CHF).Method90 CHF (CHF group ) patients and 50 healthy subjects (control group) over the same period were selected for this study. Blood plasma BNP, serumuric acid, LVDd, LADd and LVEF between the two groups were compared. Analyzed the levels of blood plasma BNP and serum uric acid in different cardiac function group and different ultrasound parameters of left ventricular and its relationship with cardiac function and left ventricular ultrasound parameters.ResultThe blood plasma BNP, serum uric acid, LVDd, and LADd in CHF group were significantly higher than control group, and the LVEF was significantly lower than control group (P<0.05). There were signiifcant differences in blood plasma BNP and serum uric acid levels in patients with different cardiac function classiifcation (P<0.05). The blood plasma BNP and serum uric acid levels in patients with left ventricular dysfunction were signiifcantly higher than normal group (P<0.05). Blood plasma BNP level in patients with CHF was positively correlated with heart function grade, serum uric acid, LVDd and LADd, and negatively correlated with LVEF, serum uric acid and heart function, LADd and LVDd were positively correlated, and negatively correlated with LVEF.Conclusion Blood plasma BNP and serum uric acid levels are correlated with cardiac function classiifcation. They are signiifcantly increasing with the rise of heart function grade, and can be used as a predictor of heart function.
