中国医学创新
中國醫學創新
중국의학창신
Medical Innovation of China
2015年
27期
6-8,9
,共4页
ApoC-Ⅲ启动子C-482T%T-455C单核苷酸多态性%2型糖尿病
ApoC-Ⅲ啟動子C-482T%T-455C單覈苷痠多態性%2型糖尿病
ApoC-Ⅲ계동자C-482T%T-455C단핵감산다태성%2형당뇨병
ApoC-Ⅲ promoter C-482T%Single nucleotide polymorphism of T-455C%Type 2 diabetes
目的：分析探究2型糖尿病与ApoC-Ⅲ启动子C-482T和T-455C单核苷酸多态性的相关性。方法：选择2012年9月-2014年9月在本院接受治疗的50例2型糖尿病患者作为试验组，并选取同期50例接受健康体检的正常人作为对照组，分别检测两组ApoC-Ⅲ启动子C-482T和T-455C单核苷酸多态性，对比分析两组C-482T、T-455C基因型与等位基因之间的频率情况及T-455C与C-482T各基因型间ApoC-Ⅲ的浓度情况。结果：两组C-482T、T-455C等位基因C含量与T含量比较差异均无统计学意义（P>0.05）。试验组T-455C与C-482T各基因型的ApoC-Ⅲ浓度与对照组比较差异无统计学意义（P>0.05）。对照组-482TT基因型的ApoC-Ⅲ浓度高于其-482CT基因型的ApoC-Ⅲ浓度，比较差异有统计学意义（P<0.05）。结论：2型糖尿病的发病与ApoC-Ⅲ启动子C-482T和T-455C单核苷酸多态性之间并不存在相关性，但健康人体内的C-482T多态性与其血清ApoC-Ⅲ水平的变化之间存在一定的联系。
目的：分析探究2型糖尿病與ApoC-Ⅲ啟動子C-482T和T-455C單覈苷痠多態性的相關性。方法：選擇2012年9月-2014年9月在本院接受治療的50例2型糖尿病患者作為試驗組，併選取同期50例接受健康體檢的正常人作為對照組，分彆檢測兩組ApoC-Ⅲ啟動子C-482T和T-455C單覈苷痠多態性，對比分析兩組C-482T、T-455C基因型與等位基因之間的頻率情況及T-455C與C-482T各基因型間ApoC-Ⅲ的濃度情況。結果：兩組C-482T、T-455C等位基因C含量與T含量比較差異均無統計學意義（P>0.05）。試驗組T-455C與C-482T各基因型的ApoC-Ⅲ濃度與對照組比較差異無統計學意義（P>0.05）。對照組-482TT基因型的ApoC-Ⅲ濃度高于其-482CT基因型的ApoC-Ⅲ濃度，比較差異有統計學意義（P<0.05）。結論：2型糖尿病的髮病與ApoC-Ⅲ啟動子C-482T和T-455C單覈苷痠多態性之間併不存在相關性，但健康人體內的C-482T多態性與其血清ApoC-Ⅲ水平的變化之間存在一定的聯繫。
목적：분석탐구2형당뇨병여ApoC-Ⅲ계동자C-482T화T-455C단핵감산다태성적상관성。방법：선택2012년9월-2014년9월재본원접수치료적50례2형당뇨병환자작위시험조，병선취동기50례접수건강체검적정상인작위대조조，분별검측량조ApoC-Ⅲ계동자C-482T화T-455C단핵감산다태성，대비분석량조C-482T、T-455C기인형여등위기인지간적빈솔정황급T-455C여C-482T각기인형간ApoC-Ⅲ적농도정황。결과：량조C-482T、T-455C등위기인C함량여T함량비교차이균무통계학의의（P>0.05）。시험조T-455C여C-482T각기인형적ApoC-Ⅲ농도여대조조비교차이무통계학의의（P>0.05）。대조조-482TT기인형적ApoC-Ⅲ농도고우기-482CT기인형적ApoC-Ⅲ농도，비교차이유통계학의의（P<0.05）。결론：2형당뇨병적발병여ApoC-Ⅲ계동자C-482T화T-455C단핵감산다태성지간병불존재상관성，단건강인체내적C-482T다태성여기혈청ApoC-Ⅲ수평적변화지간존재일정적련계。
Objective:To analyze and explore the relationship between single nucleotide polymorphisms of ApoC-Ⅲ promoter C-482T,T-455C and type 2 diabetes.Method:50 patients with type 2 diabetes who accepted treatment in our hospital from September 2012 to September 2014 were selected as the test group,50 health people who accepted health examination at the same time were selected as the control group.The single nucleotide polymorphisms(SNPs) of C-482T and T-455C of the two groups were detected.The frequency of genotype and allele of C-482T and T-455C in the two groups,the concentration of ApoC-Ⅲ in different genotypes of C-482T and T-455C were analyzed and compared. Result:The differences in the content of C,T in C-482T and T-455C of the two groups were not statistically significant (P>0.05).The differences in concentrations of ApoC-Ⅲ in different genotypes of C-482T and T-455C of the two groups were not statistically significant(P>0.05).In the control group,the concentration of ApoC-Ⅲ in genotype of -482TT was higher than that in genotype of -482CT,the difference was statistically significant(P<0.05).Conclusion:There is no relationship between single nucleotide polymorphisms of ApoC-Ⅲ promoter C-482T,T-455C and type 2 diabetes.But in the health people,the polymorphism of C-482T has a relationship with the level of serum ApoC-Ⅲ.
