中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
Chinese Journal of the Frontiers of Medical Science (Electronic Version)
2015年
8期
85-88
,共4页
王建%李庆士%李龙海%胡冬梅%董葆
王建%李慶士%李龍海%鬍鼕梅%董葆
왕건%리경사%리룡해%호동매%동보
IgA肾病%病理分型%临床表现
IgA腎病%病理分型%臨床錶現
IgA신병%병리분형%림상표현
IgA nephropathy%Pathological classiifcation%Clinical manifestation
目的：总结分析不同IgA肾病病理分型及临床表现。方法回顾性分析2010年1月至2014年7月本院收治的277例IgA肾病患者的临床资料，均接受肾脏病理检查，分析病理分型与各临床指标间的关系。结果轻度系膜增生性IgA肾病、中度系膜增生性IgA肾病、局灶增生性IgA肾病伴缺血性肾损伤、局灶增生硬化性IgA肾病伴部分新月体形成、局灶增生性IgA肾病伴急性肾小管损伤、局灶增生性IgA肾病伴部分肾小球硬化、局灶增生性IgA肾病分别占11.91%、0.36%、3.61%、0.72%、3.61%、4.33%、63.54%，后五种分型IgA肾病患者血肌酐水平明显高于前两种分型；不同病理分型IgA肾病患者24小时尿蛋白定量比较无显著差异。结论不同病理分型IgA肾病临床表现差异较明显，及时行肾穿刺活检对早期治疗具有重要的指导意义，值得临床推广。
目的：總結分析不同IgA腎病病理分型及臨床錶現。方法迴顧性分析2010年1月至2014年7月本院收治的277例IgA腎病患者的臨床資料，均接受腎髒病理檢查，分析病理分型與各臨床指標間的關繫。結果輕度繫膜增生性IgA腎病、中度繫膜增生性IgA腎病、跼竈增生性IgA腎病伴缺血性腎損傷、跼竈增生硬化性IgA腎病伴部分新月體形成、跼竈增生性IgA腎病伴急性腎小管損傷、跼竈增生性IgA腎病伴部分腎小毬硬化、跼竈增生性IgA腎病分彆佔11.91%、0.36%、3.61%、0.72%、3.61%、4.33%、63.54%，後五種分型IgA腎病患者血肌酐水平明顯高于前兩種分型；不同病理分型IgA腎病患者24小時尿蛋白定量比較無顯著差異。結論不同病理分型IgA腎病臨床錶現差異較明顯，及時行腎穿刺活檢對早期治療具有重要的指導意義，值得臨床推廣。
목적：총결분석불동IgA신병병리분형급림상표현。방법회고성분석2010년1월지2014년7월본원수치적277례IgA신병환자적림상자료，균접수신장병리검사，분석병리분형여각림상지표간적관계。결과경도계막증생성IgA신병、중도계막증생성IgA신병、국조증생성IgA신병반결혈성신손상、국조증생경화성IgA신병반부분신월체형성、국조증생성IgA신병반급성신소관손상、국조증생성IgA신병반부분신소구경화、국조증생성IgA신병분별점11.91%、0.36%、3.61%、0.72%、3.61%、4.33%、63.54%，후오충분형IgA신병환자혈기항수평명현고우전량충분형；불동병리분형IgA신병환자24소시뇨단백정량비교무현저차이。결론불동병리분형IgA신병림상표현차이교명현，급시행신천자활검대조기치료구유중요적지도의의，치득림상추엄。
ObjectiveTo summarize different pathologic classiifcation and clinical manifestations of IgA nephropathy.MethodA retrospective analysis of 277 patients with IgA nephropathy in our hospital from January 2010 to July 2014, all of these patients had taken kidney pathologic examination, the pathologic classification and the relationship among various clinical indexes were analyzed.ResultMild mesangial proliferative IgA nephropathy, moderate mesangial proliferative IgA nephropathy, focal proliferative IgA nephropathy with ischemic renal injury, focal hyperplasia sclerosing IgA nephropathy with partial crescent formation, focal proliferative IgA nephropathy with acute renal tubular injury, focal proliferative IgA nephropathy with partial glomerular sclerosis, focal proliferative IgA nephropathy respectively accounted for 11.91%, 0.36%, 3.61%, 0.72%, 3.61%, 4.33%, 63.54%; the serum creatinine levels of the last five classiifcations was signiifcantly higher than that of the ifrst two and the difference of 24h urinary protein level was not statistically signiifcant among different pathological classiifcation.ConclusionClinical differences among different pathologic classiifcation of IgA nephropathy are obvious. Getting renopuncture biopsy in time has an important guiding signiifcance in the early treatment and deserve to be expanded clinically.
