CAJ | 학술논문

近年来,越来越多的研究表明维生素D不仅在钙磷调节和骨密度的维持中起到至关重要的作用,其作为新的开环甾体激素在免疫调节和维持中枢神经系统正常生理功能中的作用也日益引起研究者的重视.包括多发性硬化症、阿尔兹海默病、帕金森病、精神分裂症、抑郁症等多种神经精神疾病经常伴随着维生素D的缺乏和免疫系统的激活.本文就近年来维生素D在神经免疫调节中的作用以及其与这些多种神经精神疾病的关系进行综述.
근년래,월래월다적연구표명유생소D불부재개린조절화골밀도적유지중기도지관중요적작용,기작위신적개배치체격소재면역조절화유지중추신경계통정상생리공능중적작용야일익인기연구자적중시.포괄다발성경화증、아이자해묵병、파금삼병、정신분렬증、억욱증등다충신경정신질병경상반수착유생소D적결핍화면역계통적격활.본문취근년래유생소D재신경면역조절중적작용이급기여저사다충신경정신질병적관계진행종술.
Over the last decade,a growing body of evidence has indicated that vitamin D is not only crucial in maintaining calcium-phosphorus homeostasis and bone density,but also implicated in the regulation of immune system and the maintenance of the normal function of central nervous system.A variety of neuropsychiatric disorders such as multiple sclerosis,Alzheimer's disease,Parkinson's disease,schizophrenia,and depression are suggested to be associated with vitamin D deficiency and immune activation.In this review,we summarize the recent key findings concerning the effect of vitamin D on neuroimmmune modulation and its potential role in those neuropsychiatric disorders.