CAJ | 학술논문

二肽基肽酶-Ⅳ(DPP-Ⅳ/CD26,EC 3.4.14.5)是一种跨膜丝氨酸多肽酶,分布广泛,作用多向.既可作为二肽酶发挥水解多肽的功能,从而调节肽类激素、神经肽、细胞因子和生长因子的活性;亦可作为表面抗原与其他分子或蛋白共同合作,介导细胞与基质、细胞与细胞之间的相互作用.在免疫激活、炎症反应和肿瘤发生中起到各种调节作用.本文对DPP-Ⅳ/CD26的结构、分布、生理功能和病理状态下的变化进行简要综述.
이태기태매-Ⅳ(DPP-Ⅳ/CD26,EC 3.4.14.5)시일충과막사안산다태매,분포엄범,작용다향.기가작위이태매발휘수해다태적공능,종이조절태류격소、신경태、세포인자화생장인자적활성;역가작위표면항원여기타분자혹단백공동합작,개도세포여기질、세포여세포지간적상호작용.재면역격활、염증반응화종류발생중기도각충조절작용.본문대DPP-Ⅳ/CD26적결구、분포、생리공능화병리상태하적변화진행간요종술.
Dipeptidyl peptidase-Ⅳ (DPP-Ⅳ/CD26,EC 3.4.14.5),a transmembrane serine polypeptidase,is widely distributed and has diverse effects.As a dipeptidase,DPP-Ⅳ/CD26 could not only regulate the activity of many peptide hormones,neuropeptides,cytokines and growth factors via its peptidase function,but also mediate cell-matrix and cell-cell contact through interactions with other molecules or proteins as a surface antigen.DPP-Ⅳ/CD26 plays a regulatory role in immune activation,inflammation and tumorigenesis.This review covers the structure,distribution,physiological functions and changes in pathological state of Dpp-Ⅳ/CD26.