CAJ | 학술논문

目的：探讨冠心病（ CAD）患者糖化血清白蛋白（ GA）的表达水平及其相关性。方法选择该院2011年1月至2012年12月内科住院患者124例，分为CAD与非CAD组，检测并比较两组GA、糖化血红蛋白（HbA1c）、餐后2 h血糖（2 h PG）等指标。 CAD的诊断采用冠状动脉造影。应用Logistic回归分析GA的独立危险性。结果检出CAD患者82例（66．13％），其GA、2 h PG、HbA1c水平均高于对照组（P＜0．05）。亚组分析显示，正常糖耐量组CAD患者GA明显较高（P＝0．006）；冠状动脉单支病变和多支病变者GA水平均高于无CAD者（P＝0．028，0．043）；高血糖组亚组分析结果同正常糖耐量组。 Logistic多因素回归分析显示，在所有对象和不同亚组分析中，GA均是CAD的独立危险因素（ P＜0．05）。结论 GA在高血糖或者正常糖耐量水平的CAD患者中均明显升高，是CAD发生的独立危险因素。
목적：탐토관심병（ CAD）환자당화혈청백단백（ GA）적표체수평급기상관성。방법선택해원2011년1월지2012년12월내과주원환자124례，분위CAD여비CAD조，검측병비교량조GA、당화혈홍단백（HbA1c）、찬후2 h혈당（2 h PG）등지표。 CAD적진단채용관상동맥조영。응용Logistic회귀분석GA적독립위험성。결과검출CAD환자82례（66．13％），기GA、2 h PG、HbA1c수평균고우대조조（P＜0．05）。아조분석현시，정상당내량조CAD환자GA명현교고（P＝0．006）；관상동맥단지병변화다지병변자GA수평균고우무CAD자（P＝0．028，0．043）；고혈당조아조분석결과동정상당내량조。 Logistic다인소회귀분석현시，재소유대상화불동아조분석중，GA균시CAD적독립위험인소（ P＜0．05）。결론 GA재고혈당혹자정상당내량수평적CAD환자중균명현승고，시CAD발생적독립위험인소。
Objective To investigate the expression of glycated albumin in patients with coronary artery disease ( CAD) and their correlation.Methods 124 patients were divided into CAD and non-CAD groups according to the diagnostic criteria of coronary angiography. And then, the levels of glycated albumin (GA), glycosylated hemoglobin (HbA1c), postprandial 2 h plasma glucose (2 h PG) psychosis indicators were compared between two groups.Results CAD was occurred 66.13%(82/124) .The levels of GA, 2 h PG, HbAlc in CAD group were higher than those in non-CAD group(all P<0.05).In the subgroup of normal glucose tolerance group, CAD patients had a high level of GA than that of non-CAD patients(P=0.006).The level of GA was higher in CAD patients with one vessel (P=0.028) and multi-vessel lesions(P=0.043) than that in non-CAD groups; the similar results obtained in hyperglycemia group.GA was an independent risk factor of CAD among all subjects (P<0.05).Conclusions The level of GA becomes elevated in CAD patients with normal glucose tolerance or hyperglycemia.And it is an independent risk factor of CAD.