中国医药指南
中國醫藥指南
중국의약지남
Guide of China Medicine
2015年
27期
14-15
,共2页
链球菌感染后反应性关节炎%风湿热%临床分析%儿童
鏈毬菌感染後反應性關節炎%風濕熱%臨床分析%兒童
련구균감염후반응성관절염%풍습열%림상분석%인동
Poststreptococcal reactive arthritis%Rheumatoid fever%Clinical analysis%Child
目的:为提高对儿童链球菌感染后反应性关节炎(PSRA)的认识。方法回顾性分析了30例PSRA患儿的临床治疗特点,并与12例风湿热(RF)对照比较。结果两组髋、膝、踝、肩、肘、腕等大关节易受累,指趾关节亦可受累,PSRA组有3例(10%)累及骶髂关节, RF组骶髂关节无累及。PSRA组表现为持续性不对称性关节疼痛或肿痛,疼痛持续时间10~210 d,平均(48.67±47.987)d,肿胀持续时间7~60 d,平均(19.87±15.265)d,而RF组表现为一过性对称性关节疼痛或肿痛,时间均未超过2周。WBC、CRP、ESR、CK-MB增高两组差异均无统计学意义(矫正χ2=0.082、3.382、1.491、2.123,P均>0.05),ANA、HLA-B27、RF阳性PSRA组均为2/30(6.67%),属正常人群分布,RF组未见增高病例。治疗上PSRA组对单独应用非甾体类消炎镇痛药及青霉素类,临床疗效差,而RF组对非甾体类消炎镇痛药及青霉素类治疗反应好。结论 PSRA血清学指标与RF相似,但关节疼痛或肿痛时间长于RF,对非甾体类消炎镇痛药的反应较RF差。PSRA可能是不同于RF的一个独立疾病。
目的:為提高對兒童鏈毬菌感染後反應性關節炎(PSRA)的認識。方法迴顧性分析瞭30例PSRA患兒的臨床治療特點,併與12例風濕熱(RF)對照比較。結果兩組髖、膝、踝、肩、肘、腕等大關節易受纍,指趾關節亦可受纍,PSRA組有3例(10%)纍及骶髂關節, RF組骶髂關節無纍及。PSRA組錶現為持續性不對稱性關節疼痛或腫痛,疼痛持續時間10~210 d,平均(48.67±47.987)d,腫脹持續時間7~60 d,平均(19.87±15.265)d,而RF組錶現為一過性對稱性關節疼痛或腫痛,時間均未超過2週。WBC、CRP、ESR、CK-MB增高兩組差異均無統計學意義(矯正χ2=0.082、3.382、1.491、2.123,P均>0.05),ANA、HLA-B27、RF暘性PSRA組均為2/30(6.67%),屬正常人群分佈,RF組未見增高病例。治療上PSRA組對單獨應用非甾體類消炎鎮痛藥及青黴素類,臨床療效差,而RF組對非甾體類消炎鎮痛藥及青黴素類治療反應好。結論 PSRA血清學指標與RF相似,但關節疼痛或腫痛時間長于RF,對非甾體類消炎鎮痛藥的反應較RF差。PSRA可能是不同于RF的一箇獨立疾病。
목적:위제고대인동련구균감염후반응성관절염(PSRA)적인식。방법회고성분석료30례PSRA환인적림상치료특점,병여12례풍습열(RF)대조비교。결과량조관、슬、과、견、주、완등대관절역수루,지지관절역가수루,PSRA조유3례(10%)루급저가관절, RF조저가관절무루급。PSRA조표현위지속성불대칭성관절동통혹종통,동통지속시간10~210 d,평균(48.67±47.987)d,종창지속시간7~60 d,평균(19.87±15.265)d,이RF조표현위일과성대칭성관절동통혹종통,시간균미초과2주。WBC、CRP、ESR、CK-MB증고량조차이균무통계학의의(교정χ2=0.082、3.382、1.491、2.123,P균>0.05),ANA、HLA-B27、RF양성PSRA조균위2/30(6.67%),속정상인군분포,RF조미견증고병례。치료상PSRA조대단독응용비치체류소염진통약급청매소류,림상료효차,이RF조대비치체류소염진통약급청매소류치료반응호。결론 PSRA혈청학지표여RF상사,단관절동통혹종통시간장우RF,대비치체류소염진통약적반응교RF차。PSRA가능시불동우RF적일개독립질병。
ObjectiveIn order to enhance the knowledge about poststreptococcal reactive arthritis in children.Methods30 children with poststreptococcal reactive arthritis and 12 children with rheumatoid fever were entered into study.ResultsHip, knee, ankle, shoulder, elbow and wrist joints were regularly involved, although small joints and axial involvement occurred as well in two groups. The arthritis seen in PSRA was typically nonmigratory, more severe, and prolonged and usually had a poor response to nonsteroid anti-inlfammatory drugs, compared with the arthritis in RF, which was characterized by an exquisite sensitivity to nonsteroid anti-inlfammatory drugs and a migratory self-limiting disease course. Signiifcant difference wasn’t detected in laboratory features between PSRA and RF.ConclusionThere are differences in clinical festures and similarities in laboratory features between PSTA and RF. Unlike RF, PSRA responds relatively poorly to nonsteroid anti-inlfammatory drugs. PSRA may be a homogeneous clinical syndrome different from RF.