中国老年学杂志
中國老年學雜誌
중국노년학잡지
Chinese Journal of Gerontology
2015年
19期
5457-5458
,共2页
丹参注射液%急性脑梗死%凋亡%可溶性凋亡相关因子( sFas)%可溶性凋亡相关因子配体( sFasL)
丹參註射液%急性腦梗死%凋亡%可溶性凋亡相關因子( sFas)%可溶性凋亡相關因子配體( sFasL)
단삼주사액%급성뇌경사%조망%가용성조망상관인자( sFas)%가용성조망상관인자배체( sFasL)
Danshen injection%Acute cerebral infarction%Apoptosis%Soluble apoptosis related factor( sFas)%Soluble apoptosis relat-ed factor ligands( sFasL)
目的：探讨丹参注射液对急性脑梗死（ACI）患者血清可溶性凋亡相关因子（sFas）和可溶性凋亡相关因子配体（sFasL）水平的影响。方法选取312例ACI患者作为研究对象，根据治疗方式随机分为对照组和观察组，对照组给予常规治疗，观察组在常规治疗基础上给予静脉滴注丹参注射液。两组治疗14 d后对疗效进行评定，并对两组患者血清中sFas和sFasL水平进行动态分析，并分析sFas和sFasL水平与预后的关系。结果对照组和观察组的治疗有效率分别为73．72％和89．10％，观察组治疗有效率明显高于对照组（ P＜0．05）。对照组和观察组在治疗后血清中sFas和sFasL水平均呈下降趋势。其中观察组患者血清中sFas和sFasL水平在治疗后第2天显著低于治疗前，而对照组患者在治疗后第4天血清sFas和sFasL水平显著低于治疗前（P＜0．05）。观察组患者血清中sFas和sFasL下降幅度明显高于对照组（P＜0．05）。结论丹参注射液治疗ACI具有较好的疗效，可显著下调患者血清sFas和sFasL水平，对保护神经细胞功能具有重要意义。
目的：探討丹參註射液對急性腦梗死（ACI）患者血清可溶性凋亡相關因子（sFas）和可溶性凋亡相關因子配體（sFasL）水平的影響。方法選取312例ACI患者作為研究對象，根據治療方式隨機分為對照組和觀察組，對照組給予常規治療，觀察組在常規治療基礎上給予靜脈滴註丹參註射液。兩組治療14 d後對療效進行評定，併對兩組患者血清中sFas和sFasL水平進行動態分析，併分析sFas和sFasL水平與預後的關繫。結果對照組和觀察組的治療有效率分彆為73．72％和89．10％，觀察組治療有效率明顯高于對照組（ P＜0．05）。對照組和觀察組在治療後血清中sFas和sFasL水平均呈下降趨勢。其中觀察組患者血清中sFas和sFasL水平在治療後第2天顯著低于治療前，而對照組患者在治療後第4天血清sFas和sFasL水平顯著低于治療前（P＜0．05）。觀察組患者血清中sFas和sFasL下降幅度明顯高于對照組（P＜0．05）。結論丹參註射液治療ACI具有較好的療效，可顯著下調患者血清sFas和sFasL水平，對保護神經細胞功能具有重要意義。
목적：탐토단삼주사액대급성뇌경사（ACI）환자혈청가용성조망상관인자（sFas）화가용성조망상관인자배체（sFasL）수평적영향。방법선취312례ACI환자작위연구대상，근거치료방식수궤분위대조조화관찰조，대조조급여상규치료，관찰조재상규치료기출상급여정맥적주단삼주사액。량조치료14 d후대료효진행평정，병대량조환자혈청중sFas화sFasL수평진행동태분석，병분석sFas화sFasL수평여예후적관계。결과대조조화관찰조적치료유효솔분별위73．72％화89．10％，관찰조치료유효솔명현고우대조조（ P＜0．05）。대조조화관찰조재치료후혈청중sFas화sFasL수평균정하강추세。기중관찰조환자혈청중sFas화sFasL수평재치료후제2천현저저우치료전，이대조조환자재치료후제4천혈청sFas화sFasL수평현저저우치료전（P＜0．05）。관찰조환자혈청중sFas화sFasL하강폭도명현고우대조조（P＜0．05）。결론단삼주사액치료ACI구유교호적료효，가현저하조환자혈청sFas화sFasL수평，대보호신경세포공능구유중요의의。
Objective To explore effect of Danshen injection on serum soluble apoptosis related factor soluble apoptosis related fac-tor ligands sFas and sFasL in patients with acute cerebral infarction ( ACI) .Methods 312 ACI patients were divided into control and ob-serve groups according to treatment.Patients in the control group were treated with routine therapy.Patients in the observe group were treated with Danshen injection on the basis of routine therapy.Total treatment efficacy and dynamic change of sFas and sFasL were analyzed.Results Total treatment efficacy in control and observe groups was 73.72%and 89.10%respectively.Total treatment efficacy in observe group sig-nificantly higher than that of control (P<0.05).The sFas and sFasL level in control and observe groups exhibited downtrend.After treatment on 2 days,the sFas and sFasL level in observe group significantly reduced than before treatment(P<0.05),but the sFas and sFasL level in control group after treatment on 4 days significantly reduced than before treatment(P<0.05).The drop of sFas and sFasL level in observe group was significantly higher than that of control group (P<0.05).Conclusions Danshen injection has better efficacy and could reduce se-rum sFas and sFasL level in ACI patients.It plays an important role in protecting nerve cell function.
