CAJ | 학술논문

目的：比较门冬胰岛素30与人胰岛素30R治疗老年2型糖尿病的疗效和安全性。方法将66例老年2型糖尿病患者随机分成门冬胰岛素30组与人胰岛素30R组各33例，采用门冬胰岛素30每日3次皮下注射与人胰岛素30R每日2次皮下注射，进行8周的观察。比较治疗8周后两组8个时点的血糖，8周后糖化血红蛋白（HbA1c），低血糖的差异。结果门冬胰岛素30组与人胰岛素30R组治疗后血糖， HbA1c较治疗前均明显下降（P<0.01）。门冬胰岛素30组餐前、餐后2 h血糖低于人胰岛素30R组，差异有统计学意义（P<0.05），门冬胰岛素30组低血糖发生率低于人胰岛素30R组，差异无统计学意义（P>0.05）。结论对于老年2型糖尿病患者3次/天注射门冬胰岛素30较人胰岛素30R 2次/天对餐后2 h血糖控制更有效，减少低血糖风险，为患者提供更灵活的用餐时间。
목적：비교문동이도소30여인이도소30R치료노년2형당뇨병적료효화안전성。방법장66례노년2형당뇨병환자수궤분성문동이도소30조여인이도소30R조각33례，채용문동이도소30매일3차피하주사여인이도소30R매일2차피하주사，진행8주적관찰。비교치료8주후량조8개시점적혈당，8주후당화혈홍단백（HbA1c），저혈당적차이。결과문동이도소30조여인이도소30R조치료후혈당， HbA1c교치료전균명현하강（P<0.01）。문동이도소30조찬전、찬후2 h혈당저우인이도소30R조，차이유통계학의의（P<0.05），문동이도소30조저혈당발생솔저우인이도소30R조，차이무통계학의의（P>0.05）。결론대우노년2형당뇨병환자3차/천주사문동이도소30교인이도소30R 2차/천대찬후2 h혈당공제경유효，감소저혈당풍험，위환자제공경령활적용찬시간。
ObjectiveTo compare the efifcacy and safety of aspart insulin 30 elderly type 2 diabetic treatment with human insulin 30R.Method66 elderly patients with type 2 diabetes were randomly divided into 30 groups of insulin aspart with human insulin 30R group of 33 cases, using aspart insulin 30 three times daily subcutaneous injection of human insulin 30R daily subcutaneous injection, carried out eight weeks observation. The two groups of eight time points after 8 weeks of comparative treatment of blood glucose, glycosylated hemoglobin (HbA1c), low blood sugar difference after 8 weeks.ResultsBlood glucose after insulin aspart 30 30R group treatment with human insulin, HbA1c than before treatment were signiifcantly decreased (P<0.01). Insulin aspart 30 group fasting and 2h postprandial blood sugar lower than the 30R group of human insulin, the difference was statistically signiifcant (P<0.05), insulin aspart 30 group the incidence of hypoglycemia is lower than the 30R group of human insulin, the difference was not statistically signiifcance (P>0.05). Conclusion3 times per day injection of insulin aspart in elderly type 2 diabetic patients 30 compared with human insulin 30R 2 times per day on 2-hour postprandial blood glucose control is more effective, reducing the risk of hypoglycemia for patients to provide more lfexible meal times.