CAJ | 학술논문

目的：探讨结肠电刺激对应激诱导产生的内脏高敏感性的影响。方法48只大鼠等分为模型组、对照组，模型组由双重应激诱导产生，其内脏高敏感性程度由肌电图及腹部撤退反射的分数来评估，对照组不接受双重应激。建模后在所有大鼠的结肠浆膜层包埋刺激电极，待手术恢复后分别对各组大鼠进行长脉冲电刺激、短串脉冲电刺激、无电刺激，刺激结束后再次对模型组、对照组大鼠的内脏高敏感性程度进行评估。结果通过应激诱导，模型组大鼠对结肠扩张压力的敏感性与对照组比较有显著增加(P<0.01)。串短脉冲、长脉冲结肠电刺激相较无电刺激能够显著降低大鼠的内脏高敏感性(P<0.01)。结论串短脉冲、长脉冲结肠电刺激能够显著降低大鼠内脏高敏感性。
목적：탐토결장전자격대응격유도산생적내장고민감성적영향。방법48지대서등분위모형조、대조조，모형조유쌍중응격유도산생，기내장고민감성정도유기전도급복부철퇴반사적분수래평고，대조조불접수쌍중응격。건모후재소유대서적결장장막층포매자격전겁，대수술회복후분별대각조대서진행장맥충전자격、단천맥충전자격、무전자격，자격결속후재차대모형조、대조조대서적내장고민감성정도진행평고。결과통과응격유도，모형조대서대결장확장압력적민감성여대조조비교유현저증가(P<0.01)。천단맥충、장맥충결장전자격상교무전자격능구현저강저대서적내장고민감성(P<0.01)。결론천단맥충、장맥충결장전자격능구현저강저대서내장고민감성。
Objective To investigate whether stress-induced visceral hypersensitivity could be alleviated by colonic electrical stimulation (CES). Methods 48 male rats were divided into model group and control group,visceral hyper-sensitivity model was induced by a 6 d heterotypic intermittent stress,the extent of visceral hypersensitivity was quantified by electromyography and abdominal withdrawal reflx scores. After the modeling,all rats were equipped with electrodes in de-scending colon. After recovering from surgery,CES with long pulses,CES with trains of short pulses,sham CES was per-formed. Finally,the extent of visceral hypersensitivity will be quantified again in model group. Results Rats displayed an increased sensitivity to colorectal distention,after a 6 d heterotypic intermittent stress compared to control group at different distention pressures (P<0. 01). CES with trains of short pulses and long pulses significantly attenuated the hypersensitive responses to colorectal distention compared with sham CES group (P<0. 01). Conclusion CES with long pulses,CES with trains of short pulses all can significantly alleviate stress-induced visceral hypersensitivity.