CAJ | 학술논문

目的探讨雾化吸入布地奈德混悬液联合妥洛特罗治疗小儿喘息性肺炎的临床疗效.方法选取113例喘息性支气管肺炎患儿,分为观察组(n=60)和对照组(n=53).对照组仅给予布地奈德治疗,观察组采用布地奈德联合妥洛特罗,比较两组患者血清细胞因子水平、炎症指标及临床疗效.结果治疗后,观察组患儿外周血嗜酸粒细胞阳离子蛋白、嗜酸粒细胞显著降低,与对照组比较差异具有统计学意义(P＜0.05).观察组患者血清IL-5、IL-6水平显著降低,IFN-γ、IL-12水平显著升高,与对照组比较差异具有统计学意义(P＜0.05).观察组疗效显著优于对照组(93.3％ vs 79.2％),两组比较差异具有统计学意义(x2=4.852,P =0.028).结论雾化吸入布地奈德混悬液联合妥洛特罗治疗小儿喘息性肺炎,可纠正Th1/Th2免疫漂移,降低炎症反应,提高临床疗效,值得临床推广使用.
목적 탐토무화흡입포지내덕혼현액연합타락특라치료소인천식성폐염적림상료효.방법 선취113례천식성지기관폐염환인,분위관찰조(n=60)화대조조(n=53).대조조부급여포지내덕치료,관찰조채용포지내덕연합타락특라,비교량조환자혈청세포인자수평、염증지표급림상료효.결과 치료후,관찰조환인외주혈기산립세포양리자단백、기산립세포현저강저,여대조조비교차이구유통계학의의(P＜0.05).관찰조환자혈청IL-5、IL-6수평현저강저,IFN-γ、IL-12수평현저승고,여대조조비교차이구유통계학의의(P＜0.05).관찰조료효현저우우대조조(93.3％ vs 79.2％),량조비교차이구유통계학의의(x2=4.852,P =0.028).결론 무화흡입포지내덕혼현액연합타락특라치료소인천식성폐염,가규정Th1/Th2면역표이,강저염증반응,제고림상료효,치득림상추엄사용.
Objective To evaluate the efficacy of budesonide suspension atomization inhalation combined with tulobuterol in treatment of children asthmatic pneumonia.Methods 113 children of asthmatic pneumonia were divided into observation group (n =60) and control group (n =53).Budesonide suspension atomization inhalation combined with tulobuterol was used in observation group and budesonide suspension atomization inhalation alone was used in control group.The levels of serum cytokines,inflammatory markers and clinical efficacy were compared between the two groups.Results After treatment,the eosinophil cationic protein and eosinophil of observation group significantly reduced,there was statistical difference between the two groups (P ＜0.05).In observation group,the levels of interleukin-5 and interleukin-6 significantly reduced,interferon-γ and interleukin-12 significantly increased,there was statistical difference between the two groups (P ＜ 0.05).The curative effect of observation group was significantly better than that of control group (93.3％ vs 79.2％,x2=4.852,P =0.028).Conclusions Budesonide suspension atomization inhalation combined with tulobuterol in treatment of children asthmatic pneumonia can correct Th1/Th2 immune drift,reduce the inflammatory reaction,improve the clinical curative effect,and is worth clinical promotion.