CAJ | 학술논문

纳米医学是纳米技术的分支，其将纳米技术的原理与方法应用于医学。纳米粒子独特的尺寸使其具有独特和优良的材料特性。纳米粒子以最小的侵袭性进行药物递送，提高了药物治疗的靶向性。乳腺癌是女性最常见的恶性肿瘤，全球范围内发病率正逐年攀升。传统的治疗方法虽有效，但存在诸多不足。近年来纳米药物的快速发展，为解决这些难题提供了新的思路与方案。纳米载药系统种类繁多，包括脂质体、聚合物、抗体、金属、磁性物质、碳、陶等多种有机或无机材料。纳米药物的靶向策略包括被动靶向和主动靶向等，均可增强药物在肿瘤部位的蓄积。特定的纳米粒子也可直接杀伤肿瘤细胞。随着纳米药物的快速发展，其在乳腺癌的临床应用也日趋广泛，已有多种纳米药物进入临床研究或上市。
납미의학시납미기술적분지，기장납미기술적원리여방법응용우의학。납미입자독특적척촌사기구유독특화우량적재료특성。납미입자이최소적침습성진행약물체송，제고료약물치료적파향성。유선암시녀성최상견적악성종류，전구범위내발병솔정축년반승。전통적치료방법수유효，단존재제다불족。근년래납미약물적쾌속발전，위해결저사난제제공료신적사로여방안。납미재약계통충류번다，포괄지질체、취합물、항체、금속、자성물질、탄、도등다충유궤혹무궤재료。납미약물적파향책략포괄피동파향화주동파향등，균가증강약물재종류부위적축적。특정적납미입자야가직접살상종류세포。수착납미약물적쾌속발전，기재유선암적림상응용야일추엄범，이유다충납미약물진입림상연구혹상시。
Objective Nanomedicine is a branch of nanotechnology; it applies scientific principles and established methods of nanotechnology in healthcare. Small sized nanoparticles exhibit unique material properties. Nanoparticle therapeutic agents can be delivered with minimal invasiveness in vivo,and react more specifically to target tissues.Breast cancer is the most common cancer among women.Its incidence increases every year globally.Conventional therapeutic methods for breast cancer are effective,but have many limitations.In recent years the rapid development of nanotechnology medicine provides new solutions for those problems.There are many types of nanoengineered drug delivery systems (nDDS),each with distinguishing properties, including organic and inorganic materials, for example liposomes, polymers, antibodies, metals, magnets, carbons and ceramics. Nanomedicine may have passive and active targeting strategies. Both can enhance the accumulation of the drug in tumor sites. Specific nanoparticles can also kill or damage tumor cells.As its research advances fast,a wide application of nanomedicine in treating breast cancer is getting adopted.Many agents and formulations of nanomedicine are approved for clinical trials or approved for prescription.