CAJ | 학술논문

目的：探讨成人肾上腺皮质癌的诊断及治疗方法。方法回顾性分析2002～2010年于本院手术治疗并被病理证实的28例成人肾上腺皮质癌患者的临床资料，年龄18～78岁，平均50.2岁。所有患者均行内分泌及影像学检查。结果临床Ⅰ期6例，Ⅱ期10例，Ⅲ期4例，Ⅳ期8例。其中20例患者完整切除肿瘤，8例患者行减瘤手术。随访6个月～7年，中位生存期为14.2个月。未完全切除肿瘤者生存期均未超过12个月。16例患者术后局部复发，4例临床Ⅱ期的患者复发后再次手术，术后平均存活1年。结论肾上腺皮质癌罕见，进展快、预后差，早期诊治可以提高患者存活率。手术切除是目前治疗肾上腺皮质癌的最佳方法，放、化疗等辅助治疗可作为有益补充。
목적：탐토성인신상선피질암적진단급치료방법。방법회고성분석2002～2010년우본원수술치료병피병리증실적28례성인신상선피질암환자적림상자료，년령18～78세，평균50.2세。소유환자균행내분비급영상학검사。결과림상Ⅰ기6례，Ⅱ기10례，Ⅲ기4례，Ⅳ기8례。기중20례환자완정절제종류，8례환자행감류수술。수방6개월～7년，중위생존기위14.2개월。미완전절제종류자생존기균미초과12개월。16례환자술후국부복발，4례림상Ⅱ기적환자복발후재차수술，술후평균존활1년。결론신상선피질암한견，진전쾌、예후차，조기진치가이제고환자존활솔。수술절제시목전치료신상선피질암적최가방법，방、화료등보조치료가작위유익보충。
ObjectiveTo investigate the diagnosis and treatment of adrenocortical carcinoma in adults. Method28 cases with adrenocortical carcinoma in adults from 2002 to 2010 were enrolled, which ranged from 18 to 78 years, with a mean age of 50.2 years, clinical data of them were retrospectively reviewed. Endocrinological and radiologic evaluations were performed in all cases.Result6 patients were classiifed as stageⅠ, 10 patients as stageⅡ, and 4 patients as stageⅢ, 8 patients as stageⅣ. 20 cases underwent complete resection and 8 cases incomplete resection, the media survival time was 14.2 months (followed up from 6 months to 7 years). All patients who had incomplete resection died of metastases in 12 months. Locally recurrence occurred in 16 patients, repeated resection of locally recurrent disease was performed in stageⅡ 4 patients who survived for one more year.ConclusionAdrenocortical carcinoma is a rare endocrine malignancy, often with aggressive progression and unfavorable prognosis. Early diagnosis and management can increase the survival rate. Surgery is the only potential curative treatment, chemotherapy and radiotherapy can be effective.